Synthesis and Vanilloid Receptor (TRPV1) Activity of the Enantiomers of α-Fluorinated Capsaicin

被引：24
|
作者：
Winkler, Margit [1 ,2 ]
Moraux, Thomas [1 ,2 ]
Khairy, Hesham A. [3 ]
Scott, Roderick H. [3 ]
Slawin, Alexandra M. Z. [1 ,2 ]
O'Hagan, David [1 ,2 ]
机构：
[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland
[2] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland
[3] Univ Aberdeen, Inst Med Sci, Sch Med Sci, Aberdeen AB25 2ZD, Scotland
来源：
CHEMBIOCHEM | 2009年 / 10卷 / 05期
关键词：
capsaicin; fluorinated ligands; medicinal chemistry; organofluorine; stereoselective catalysis; C-F BOND; ANALGESIC AGENTS; AGONIST ACTIVITY; SENSORY NEURONS; ANALOGS; REGION; SENSITIVITY; CHEMISTRY; ALDEHYDES; AMIDES;
D O I：
10.1002/cbic.200800709
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：823 / 828
页数：6
相关论文
共 50 条
  • [31] The vanilloid receptor TRPV1: Role in cardiovascular and gastrointestinal protection
    Peng, Jun
    Li, Yuan-Jian
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2010, 627 (1-3) : 1 - 7
  • [32] Effects of saw palmetto extract on the vanilloid receptor TRPV1
    Yamada, Shizuo
    Kato, Yoshihisa
    LUTS-LOWER URINARY TRACT SYMPTOMS, 2022, 14 (02) : 117 - 121
  • [33] Search for the function of the TRPV1 (vanilloid) receptor in the cerebellar cortex
    Kovacs, F. E.
    Schwarz, H.
    Szabo, B.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2010, 381 : 46 - 47
  • [34] Expression of functional TRPV1 vanilloid receptor in canine keratinocytes
    Cuniberti, B.
    Barbero, R.
    Vercelli, C.
    Re, G.
    JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2009, 32 : 226 - 227
  • [35] Vanilloid receptor TRPV1: hot on the tongue and inflaming the colon
    Holzer, P
    NEUROGASTROENTEROLOGY AND MOTILITY, 2004, 16 (06): : 697 - 699
  • [36] Genetic deletion of the capsaicin vanilloid receptor, TRPV1, protects mice against caerulein-induced pancreatitis
    Romac, JM
    McCall, SJ
    Humphrey, JE
    Hsu, J
    Wang, Y
    Liddle, RA
    GASTROENTEROLOGY, 2005, 128 (04) : A44 - A44
  • [37] Characterization of chronic desensitization of vanilloid receptor (TRPV1) in the rat
    Czikora, Agnes
    Rutkai, Ibolya
    Pasztor, Eniko T.
    Porszasz, Robert
    Edes, Istvan
    Papp, Zoltan
    Toth, Attila
    FASEB JOURNAL, 2012, 26
  • [38] The Vanilloid Receptor TRPV1: New Tricks for an Old Dog?
    Szallasi, A.
    NEUROPEPTIDES, 2009, 43 (05) : 450 - 450
  • [39] Vascular Expression of Transient Receptor Potential Vanilloid 1 (TRPV1)
    Sand, Claire A.
    Grant, Andrew D.
    Nandi, Manasi
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2015, 63 (06) : 449 - 453
  • [40] Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists
    Tamayo, Nuria
    Liao, Hongyu
    Stec, Markian M.
    Wang, Xianghong
    Chakrabarti, Partha
    Retz, Dan
    Doherty, Elizabeth M.
    Surapaneni, Sekhar
    Tamir, Rami
    Bannon, Anthony W.
    Gavva, Narender R.
    Norman, Mark H.
    JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (09) : 2744 - 2757
12345