Facile construction of the colchicine skeleton by a rhodium-catalyzed cyclization cycloaddition cascade

被引：0
|
作者：
Graening, T
Friedrichsen, W
Lex, J
Schmalz, HG
机构：
[1] Univ Cologne, Inst Organ Chem, D-50939 Cologne, Germany
[2] Univ Kiel, Inst Organ Chem, D-24098 Kiel, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 09期
关键词：
D O I：
10.1002/1521-3773(20020503)41:9<1524::AID-ANIE1524>3.0.CO;2-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The major alkaloid of the meadow saffron is colchicine, which displays remarkable antimitotic activity and has long been used in the treatment of acute gout and is currently being tested against a broad variety of other diseases. In a remarkable Rh-catalyzed domino transformation, the complete carbon skeleton of this important alkaloid is assembled with high efficiency (see scheme). TBS = tert-butyldimethylsilyl, TMS = trimethylsilyl.
引用
收藏
页码：1524 / 1526
页数：3
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