An Improved Synthetic Method for Sensitive Iodine Containing Tricyclic Flavonoids

被引：2

作者：

Birsa, Mihail Lucian ^{[1
]}

Sarbu, Laura G. ^{[1
]}

机构：

[1] Alexandru Ioan Cuza Univ, Dept Chem, 11 Carol 1Blvd, Iasi 700506, Romania

来源：

MOLECULES | 2022年 / 27卷 / 23期

关键词：

flavonoids; 1; 3-dithiolium salts; dithiocarbamates; ANTIBACTERIAL PROPERTIES; CATECHINS;

D O I：

10.3390/molecules27238430

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of new iodine containing synthetic tricyclic flavonoids is reported. Due to the sensitivity of the precursors to the heat and acidic conditions required for the ring closure of the 1,3-dithiolium core, a new cyclization method has been developed. It consists in the treatment of the corresponding iodine-substituted 3-dithiocarbamic flavonoids with a 1:1 (v/v) mixture of glacial acetic acid-concentrated sulfuric acid at 40 degrees C. The synthesis of the iodine-substituted 3-dithiocarbamic flavonoids has also been tuned in terms of reaction conditions.

引用

页数：8

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