Natural and Synthetic Compounds with an Antimycobacterial Activity

被引：10

作者：

Rogoza, L. N. ^{[1
]}

Salakhutdinov, N. F. ^{[1
]}

Tolstikov, G. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Siberian Div, Vorozhtsov Inst Organ Chem, Novosibirsk 630090, Russia

来源：

MINI-REVIEWS IN ORGANIC CHEMISTRY | 2009年 / 6卷 / 02期

关键词：

Tuberculosis; multidrug-resistance tuberculosis; M; tuberculosis; antimycobacterial activity; antituberculosis activity; cytotoxicity; structure-activity" relationships; MYCOBACTERIUM-TUBERCULOSIS; ANTITUBERCULAR AGENTS; AMINO-ALCOHOLS; ANTIMICROBIAL ACTIVITY; GROWTH-INHIBITION; CONSTITUENTS; DERIVATIVES; ALKALOIDS; ANTIBACTERIAL; ANALOGS;

D O I：

10.2174/157019309788167657

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review discusses the most active natural and synthetic compounds demonstrating the antimycobacterial activity at minimum inhibiting concentrations (MIC) of 5 mu g/ml or less. For better insight into the "structure-activity" relationships, we occasionally considered compounds with high values of MIC. The review covers the period from 2001 to 2007. The data are grouped according to chemical structures, namely, nitrogen-, oxygen-, and sulfur-containing heterocyclic compounds, peptide, alkaloids, terpenoids, and others.

引用

页码：135 / 151

页数：17

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