Glycosphingolipids in endocytic membrane transport

被引：26
|
作者：
Sillence, DJ [1 ]
Platt, FM [1 ]
机构：
[1] Univ Oxford, Glycobiol Inst, Dept Biochem, Oxford OX1 3QU, England
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 04期
关键词：
Niemann-Pick C; glycosphingolipid; endocytosis; annexin; Gaucher;
D O I：
10.1016/j.semcdb.2004.03.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Endocytosis leads to the internalisation of both lipids and proteins and their delivery to specific subcellular locations. This involves sorting processes that are not completely understood, but may involve interactions between lipids and proteins as well as pH and calcium gradients. This article discusses the importance of endocytosis in glycosphingolipid (GSL) synthesis as well as the potential roles of GSLs in endocytic membrane transport. Although the accumulation of GSLs in storage diseases clearly disrupts endocytic transport, increasing evidence also supports a role for GSLs in endocytosis in normal cells. (C) 2004 Elsevier Ltd. All rights reserved.
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页码：409 / 416
页数：8
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