Role of prenatal magnetic resonance imaging in fetuses with isolated severe ventriculomegaly at neurosonography: A multicenter study

被引：11

作者：

Di Mascio, Daniele ^{[1
]}

Khalil, Asma ^{[2
,3
]}

Pilu, Gianluigi ^{[4
]}

Rizzo, Giuseppe ^{[5
,6
]}

Caulo, Massimo ^{[7
]}

Liberati, Marco ^{[8
]}

Giancotti, Antonella ^{[1
]}

Lees, Christoph ^{[9
,10
]}

Volpe, Paolo ^{[11
]}

Buca, Danilo ^{[8
]}

Oronzi, Ludovica ^{[8
]}

D'Amico, Alice ^{[8
]}

Tinari, Sara ^{[8
]}

Stampalija, Tamara ^{[12
,13
]}

Fantasia, Ilaria ^{[12
]}

Pasquini, Lucia ^{[14
]}

Masini, Giulia ^{[14
]}

Brunelli, Roberto ^{[1
]}

D'Ambrosio, Valentina ^{[1
]}

Muzii, Ludovico ^{[1
]}

Manganaro, Lucia ^{[15
]}

Antonelli, Amanda ^{[15
]}

Ercolani, Giada ^{[15
]}

Ciulla, Sandra ^{[15
]}

Saccone, Gabriele ^{[16
]}

Maruotti, Giuseppe Maria ^{[16
]}

Carbone, Luigi ^{[16
]}

Zullo, Fulvio ^{[16
]}

Olivieri, Claudiana ^{[11
]}

Ghi, Tullio ^{[17
]}

Frusca, Tiziana ^{[17
]}

Dall'Asta, Andrea ^{[9
,10
,17
]}

Visentin, Silvia ^{[18
]}

Cosmi, Erich ^{[18
]}

Forlani, Francesco ^{[19
]}

Galindo, Alberto ^{[20
]}

Villalain, Cecilia ^{[20
]}

Herraiz, Ignacio ^{[20
]}

Sileo, Filomena Giulia ^{[2
,21
,22
]}

Quintero, Olivia Mendez ^{[2
]}

Salsi, Ginevra ^{[4
]}

Bracalente, Gabriella ^{[23
]}

Morales-Rosello, Jose ^{[24
,25
]}

Loscalzo, Gabriela ^{[24
,25
]}

Pellegrino, Marcella ^{[26
]}

De Santis, Marco ^{[26
]}

Lanzone, Antonio ^{[26
]}

Parazzini, Cecilia ^{[27
]}

Lanna, Mariano ^{[28
]}

Ormitti, Francesca ^{[29
]}

机构：

[1] Sapienza Univ Rome, Dept Maternal & Child Hlth & Urol Sci, Rome, Italy

[2] St George Hosp, Fetal Med Unit, London, England

[3] St Georges Univ London, Mol & Clin Sci Res Inst, Vasc Biol Res Ctr, London, England

[4] Univ Bologna, Dept Med & Surg Sci, Unit Obstet, Bologna, Italy

[5] Univ Roma Tor Vergata, Div Maternal & Fetal Med, Osped Cristo Re, Rome, Italy

[6] First IM Sechenov Moscow State Med Univ, Dept Obstet & Gynecol, Moscow, Russia

[7] Univ G dAnnunzio, Inst Adv Biomed Technol, Dept Neurosci Imaging & Clin Sci, Chieti, Italy

[8] Univ G dAnnunzio, Ctr Fetal Care & High Risk Pregnancy, Dept Obstet & Gynecol, Chieti, Italy

[9] Imperial Coll London, Inst Reprod & Dev Biol, Dept Surg & Canc, London, England

[10] Imperial Coll Healthcare NHS Trust, Queen Charlottes & Chelsea Hosp, Ctr Fetal Care, London, England

[11] Di Venere & Sarcone Hosp, Fetal Med Unit, Bari, Italy

[12] Inst Maternal & Child Hlth IRCCS Burlo Garofolo, Unit Fetal Med & Prenatal Diag, Trieste, Italy

[13] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

[14] AOU Careggi, Fetal Med Unit, Dept Women & Children Hlth, Florence, Italy

[15] Sapienza Univ Rome, Dept Radiol Anatomopathol & Oncol, Rome, Italy

[16] Federico II Univ Naples, Sch Med, Dept Neurosci Reprod Sci & Dent, Naples, Italy

[17] Univ Parma, Dept Med & Surg, Unit Surg Sci Obstet & Gynecol, Parma, Italy

[18] Univ Padua, Dept Woman & Childs Hlth, Padua, Italy

[19] Arnas Civ Hosp, Dept Obstet & Gynaecol, Palermo, Italy

[20] Univ Complutense Madrid, Univ Hosp 12 Octubre, Dept Obstet & Gynaecol, Fetal Med Unit,Maternal & Child Hlth & Dev Networ, Madrid, Spain

[21] Univ Modena & Reggio Emilia, Int Doctorate Sch Clin & Expt Med, Dept Biochem Metab & Neural Sci, Modena, Italy

[22] Azienda Unit Sanit Locale IRCCS, Unit Obstet & Gynecol, Reggio Emilia, Italy

[23] Osp Ca Foncello Treviso, Fetal Med Unit, Dept Obstet & Gynecol, Treviso, Italy

[24] Hosp Univ & Politecn La Fe, Serv Obstet, Valencia, Spain

[25] Univ Valencia, Dept Pediatr Obstet & Ginecol, Valencia, Spain

[26] Univ Cattolica Sacro Cuore, Dept Woman Child Hlth & Publ Hlth, Fdn Policlin Univ Agostino Gemelli IRCCS, Rome, Italy

[27] Univ Milan, Pediat Radiol & Neuroradiol Dept, Childrens Hosp V Buzzi, Milan, Italy

[28] V Buzzi Univ Milano, Fetal Therapy Unit Umberto Nicolini, Childrens Hosp, Milan, Italy

[29] Azienda Osped Univ Parma, Dept Radiol, Parma, Italy

[30] IRCCS Ist Sci Neurol UOC Neuroradiol, Bologna, Italy

[31] Inst Maternal & Child Hlth IRCCS Burlo Garofolo, Unit Paediat Radiol, Trieste, Italy

[32] AOU Meyer, UOC Radiodiagnost, Florence, Italy

[33] Osp Ca Foncello Treviso, UOC Neuroradiol, Treviso, Italy

[34] Complejo Hosp Univ Insular Materno Infantil Canar, Las Palmas Gran Canaria, Spain

[35] Copenhagen Univ Hosp, Ctr Fetal Med & Ultrasound, Dept Obstet, Rigshosp, Copenhagen, Denmark

[36] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[37] Aarhus Univ Hosp, Ctr Fetal Med, Dept Obstet & Gynecol, Aarhus, Denmark

[38] Aarhus Univ, Inst Clin Med, Aarhus, Denmark

[39] Univ Brescia, Dept Clin & Expt Sci, Div Obstet & Gynecol, Brescia, Italy

[40] ASST Spedali Civili, Pediat Neuroradiol Sect, Neuroradiol Unit, Brescia, Italy

[41] Univ Ferrara, Dept Med Sci, Ferrara, Italy

[42] Local Hlth Unit Avezzano Sulmona LAquila, Dept Child & Adolescent Neuropsychiat, Sulmona, Italy

[43] Univ Foggia, Dept Med & Surg Sci, Fetal Med Unit, Foggia, Italy

[44] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Obstet & Gynecol, Div Maternal Fetal Med, Philadelphia, PA 19107 USA

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2021年 / 267卷

关键词：

Ventriculomegaly; Central nervous system; Fetal magnetic resonance imaging; MRI; Fetal ultrasound; Neurosonography; Prenatal diagnosis; FETAL; MILD; HYDROCEPHALUS; EPIDEMIOLOGY; PROGRESSION; GUIDELINES; ATRIUM;

D O I：

10.1016/j.ejogrb.2021.10.014

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: The aim of this study was to report the rate of additional anomalies detected exclusively at prenatal magnetic resonance imaging (MRI) in fetuses with isolated severe ventriculomegaly undergoing neurosonography. Method: Multicenter, retrospective, cohort study involving 20 referral fetal medicine centers in Italy, United Kingdom, Spain and Denmark. Inclusion criteria were fetuses affected by isolated severe ventriculomegaly (>= 15 mm), defined as ventriculomegaly with normal karyotype and no other additional central nervous system (CNS) and extra-CNS anomalies on ultrasound. In all cases, a multiplanar assessment of fetal brain as suggested by ISUOG guidelines on fetal neurosonography had been performed. The primary outcome was the rate of additional CNS anomalies detected exclusively at fetal MRI within two weeks from neurosonography. Subgroup analyses according to gestational age at MRI (<vs >= 24 weeks of gestation) and the laterality of ventriculomegaly (unilateral vs bilateral) were also performed. Univariate and multivariate logistic regression analysis was used to analyze the data. Results: 187 fetuses with a prenatal diagnosis of isolated severe ventriculomegaly on neurosonography were included in the analysis. Additional structural anomalies were detected exclusively at prenatal MRI in 18.1% of cases. When considering the type of anomaly, malformations of cortical development were detected on MRI in 32.4% cases, while midline or acquired (hypoxemic/hemorrhagic) lesions were detected in 26.5% and 14.7% of cases, respectively. There was no difference in the rate of additional anomalies when stratifying the analysis according to either gestational age at MRI or laterality of the lesion. At multivariate logistic regression analysis, the presence of additional anomalies only found at MRI was significantly higher in bilateral compared versus unilateral ventriculomegaly (OR: 4.37, 95% CI 1.21-15.76; p = 0.04), while neither maternal body mass index, age, severity of ventricular dilatation, interval between ultrasound and MRI, nor gestational age at MRI were associated with the likelihood of detecting associated anomalies at MRI. Conclusion: The rate of associated anomalies detected exclusively at prenatal MRI in fetuses with isolated severe ventriculomegaly is lower than previously reported, but higher compared to isolated mild and moderate ventriculomegaly. Fetal MRI should be considered as a part of the prenatal assessment of fetuses presenting with isolated severe ventriculomegaly at neurosonography. (C) 2021 Elsevier B.V. All rights reserved.

引用

页码：105 / 110

页数：6

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