The rs2609255 polymorphism in the FAM13A gene is reproducibly associated with silicosis susceptibility in a Chinese population

被引:17
|
作者
Wang, Wei [1 ,2 ]
Yu, Yuhui [1 ]
Wu, Shuangshuang [3 ]
Sang, Lingli [1 ]
Wang, Xiaohui [1 ]
Qiu, Anni [1 ]
Yu, Xiaoqiao [1 ]
Li, Jingzhi [1 ]
Zhang, Lu [1 ]
Yi, Min [1 ]
Zheng, Huiting [1 ]
Gao, Yuexia [1 ]
Xiao, Jing [1 ]
Lu, Yihua [1 ]
Jiang, Liying [1 ]
Lian, Yulong [1 ]
Zhuang, Xun [1 ]
Tian, Tian [1 ]
Chu, Minjie [1 ]
机构
[1] Nantong Univ, Sch Publ Hlth, 9 Seyuan Rd, Nantong, Jiangsu, Peoples R China
[2] Ctr Dis Control & Prevent Wuxi, Dept Occupat Hlth, Wuxi, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr, Jiangsu Prov Key Lab Geriatr, Nanjing, Jiangsu, Peoples R China
基金
美国国家卫生研究院; 中国国家自然科学基金;
关键词
FAM13A; rs2609255; Silicosis; Interaction; GENOME-WIDE ASSOCIATION; OBSTRUCTIVE PULMONARY-DISEASE; WNT/BETA-CATENIN PATHWAY; LUNG-FUNCTION; FIBROSIS; LOCI; DIFFERENTIATION; INHIBITION; CELLS; COPD;
D O I
10.1016/j.gene.2018.03.098
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background: Two recent genome-wide association studies (GWASs) reported that the FAM13A gene at the 4q22 locus associated with pulmonary fibrosis (defined by rs2609255) overlapping with COPD (defined by rs6837671). We hypothesized that single-nucleotide polymorphisms (SNPs) related to lung disease (especially pulmonary fibrosis) identified in this region are also associated with the risk of silicosis. Methods: To test this hypothesis, we genotyped these two SNPs (rs2609255 and rs6837671) in a case-control study including 177 silicosis cases and 204 controls with silica dust exposure years similar to the levels for cases in a Chinese population. Results: We found that rs2609255 was significantly associated with increased silicosis risk (dominant model: OR = 1.71; 95% CI = 1.01-2.92; P = 0.047). Additionally, eQTL analysis based on the GTEx database indicated that the rs2609255 polymorphism may alter the expression level of FAM13A in lung tissues (P = 1.8 x 10(-4)). Furthermore, interaction analyses showed that rs2609255 interacts multiplicatively with years of silica dust exposure to contribute to silicosis risk (interaction P = 0.040). Conclusions: These results indicate that rs2609255 may modify silicosis susceptibility in the Chinese population.
引用
收藏
页码:196 / 201
页数:6
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