Cascade synthesis of quinazolinones from 2-aminobenzonitriles and aryl bromides via palladium-catalyzed carbonylation reaction

被引：96
|
作者：
Li, Haoquan [1 ]
He, Lin [1 ]
Neumann, Helfried [1 ]
Beller, Matthias [1 ]
Wu, Xiao-Feng [1 ]
机构：
[1] Univ Rostock eV, Leibniz Inst Katalyse, Albert Einstein Str 29a, D-18059 Rostock, Germany
来源：
GREEN CHEMISTRY | 2014年 / 16卷 / 03期
关键词：
ONE-POT SYNTHESIS; 3-COMPONENT SYNTHESIS; AQUEOUS-MEDIUM; HECK REACTION; EX-SITU; HYDRATION; NITRILES; EFFICIENT; AMIDES; BENZYL;
D O I：
10.1039/c3gc42089b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A cascade synthesis of quinazolinones from 2-aminobenzonitriles and aryl bromides through a palladium-catalyzed carbonylation reaction has been developed. Various quinazolinones were produced in moderate to excellent yields. The reactions go through aminocarbonylation of aryl bromides-hydration of nitriles-cyclization sequence. Notably, all the products were isolated by recrystallization.
引用
收藏
页码：1336 / 1343
页数：8
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