Epigenetic Regulation by Heritable RNA

被引：53

作者：

Liebers, Reinhard ^{[1
]}

Rassoulzadegan, Minoo ^{[2
,3
]}

Lyko, Frank ^{[1
]}

机构：

[1] German Canc Res Ctr, DKFZ ZMBH Alliance, Div Epigenet, Heidelberg, Germany

[2] Univ Nice Sophia Antipolis, F-06189 Nice, France

[3] CNRS, INSERM, UMR1091, UMR7277, F-06034 Nice, France

来源：

PLOS GENETICS | 2014年 / 10卷 / 04期

关键词：

NON-MENDELIAN INHERITANCE; DNA METHYLATION; NONCODING RNA; ENDOGENOUS SIRNAS; GENE-EXPRESSION; METHYLTRANSFERASE; NSUN2; DNMT2; 5-METHYLCYTOSINE; STABILITY;

D O I：

10.1371/journal.pgen.1004296

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genomic concepts are based on the assumption that phenotypes arise from the expression of genetic variants. However, the presence of non-Mendelian inheritance patterns provides a direct challenge to this view and suggests an important role for alternative mechanisms of gene regulation and inheritance. Over the past few years, a highly complex and diverse network of noncoding RNAs has been discovered. Research in animal models has shown that RNAs can be inherited and that RNA methyltransferases can be important for the transmission and expression of modified phenotypes in the next generation. We discuss possible mechanisms of RNA-mediated inheritance and the role of these mechanisms for human health and disease.

引用

页数：6

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