Drug-Drug Interaction Extraction via Attentive Capsule Network with an Improved Sliding-Margin Loss

被引:1
|
作者
Wang, Dongsheng [1 ]
Fan, Hongjie [2 ]
Liu, Junfei [3 ]
机构
[1] Peking Univ, Sch Software & Microelectron, Beijing, Peoples R China
[2] China Univ Polit Sci & Law, Dept Sci & Technol, Beijing, Peoples R China
[3] Peking Univ, Sch Elect Engn & Comp Sci, Beijing, Peoples R China
关键词
RE; DDI; Capsule network;
D O I
10.1007/978-3-030-73197-7_41
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
Relation extraction (RE) is an important task in information extraction. Drug-drug interaction (DDI) extraction is a subtask of RE in the biomedical field. Existing DDI extraction methods are usually based on recurrent neural network (RNN) or convolution neural network (CNN) which have finite feature extraction capability. Therefore, we propose a new approach for addressing the task of DDI extraction with consideration of sequence features and dependency characteristics. A sequence feature extractor is used to collect features between words, and a dependency feature extractor is designed to mine knowledge from the dependency graph of sentence. Moreover, we use an attention-based capsule network for DDI relation classification, and an improved sliding-margin loss is proposed to well learn relations. Experiments demonstrate that incorporating capsule network and improved sliding-margin loss can effectively improve the performance of DDI extraction.
引用
收藏
页码:612 / 619
页数:8
相关论文
共 50 条
  • [21] Deep Convolution Neural Networks for Drug-Drug Interaction Extraction
    Sun, Xia
    Ma, Long
    Du, Xiaodong
    Feng, Jun
    Dong, Ke
    PROCEEDINGS 2018 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM), 2018, : 1662 - 1668
  • [22] Transforming Drug-Drug Interaction Extraction from Biomedical Literature
    Zaikis, Dimitrios
    Kokkas, Stylianos
    Vlahavas, Ioannis
    PROCEEDINGS OF THE 12TH HELLENIC CONFERENCE ON ARTIFICIAL INTELLIGENCE, SETN 2022, 2022,
  • [23] Exploring convolutional neural networks for drug-drug interaction extraction
    Suarez-Paniagua, Victor
    Segura-Bedmar, Isabel
    Martinez, Paloma
    DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2017,
  • [24] Prediction of Drug Synergy and Antagonism Based on Drug-Drug Interaction Network
    Liu Wenbin
    Chen Jie
    Fang Gang
    Shi Xiaolong
    Xu Peng
    JOURNAL OF ELECTRONICS & INFORMATION TECHNOLOGY, 2020, 42 (06) : 1420 - 1427
  • [25] GraphDDI: Graph Neural Network for Prediction of Drug-Drug Interaction
    Gupta, Suyash
    Laghuvarapu, Siddhartha
    Priyakumar, U. Deva
    ARTIFICIAL INTELLIGENCE IN HEALTHCARE, PT I, AIIH 2024, 2024, 14975 : 17 - 30
  • [26] Phar-LSTM: a pharmacological representation-based LSTM network for drug-drug interaction extraction
    Huang, Mingqing
    Jiang, Zhenchao
    Guo, Shun
    PEERJ, 2023, 11
  • [27] Evaluation of pooling operations in convolutional architectures for drug-drug interaction extraction
    Víctor Suárez-Paniagua
    Isabel Segura-Bedmar
    BMC Bioinformatics, 19
  • [28] Drug-Drug Interaction Relation Extraction Based on Deep Learning: A Review
    Dou, Mingliang
    Tang, Jijun
    Tiwari, Prayag
    Ding, Yijie
    Guo, Fei
    ACM COMPUTING SURVEYS, 2024, 56 (06)
  • [29] Deep learning for drug-drug interaction extraction from the literature: a review
    Zhang, Tianlin
    Leng, Jiaxu
    Liu, Ying
    BRIEFINGS IN BIOINFORMATICS, 2020, 21 (05) : 1609 - 1627
  • [30] Drug-Drug Interaction Relation Extraction with Deep Convolutional Neural Networks
    Dewi, Ika Novita
    Dong, Shoubin
    Hu, Jinlong
    2017 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM), 2017, : 1795 - 1802