Inhibitors of MPS1: Discovery of CCT289346, a highly potent, selective and orally available preclinical candidate

被引:1
|
作者
Woodward, Hannah L.
Innocenti, Paolo
Cheung, Kwai-Ming J.
Naud, Sebastien
Hayes, Angela
Henley, Alan T.
Faisal, Amir
Mak, Grace
Box, Gary
Westwood, Isaac M.
Carter, Michael
Valenti, Melanie
Brandon, Alexis De Haven
O'Fee, Lisa
Saville, Harry
Burke, Rosemary
Van Montfort, Rob
Raynaud, Florence
Eccles, Suzanne A.
Linardopoulos, Spiros
Blagg, Julian
Hoelder, Swen
机构
关键词
D O I
10.1158/1538-7445.AM2017-193
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
193
引用
收藏
页数:2
相关论文
共 50 条
  • [1] In vitro and in vivo profile of the preclinical candidate and MPS1 kinase inhibitor CCT289346
    Woodward, Hannah
    Innocenti, Paolo
    Cheung, Kwai-Ming J.
    Naud, Sebastien
    Faisal, Amir
    Mak, Grace W.
    Hayes, Angela
    O'Fee, Lisa
    Saville, Harry
    Brandon, Alexis De Haven
    Roberts, Jennie
    Box, Gary
    Valenti, Melanie
    Heneley, Alan T.
    Walsh, Katie
    Burke, Rosemary
    Eccles, Suzanne A.
    Raynaud, Florence I.
    Van Montfort, Rob L.
    Blagg, Julian
    Linardopoulos, Spiros
    Hoelder, Swen
    CANCER RESEARCH, 2018, 78 (13)
  • [2] Discovery of orally available and potent MPS1(TTK) kinase inhibitors for anti-cancer drugs
    Lee, Younho
    Kang, Juhee
    Kang, Sein
    Kim, Hyunkyung
    Seo, Kyung-ah
    Choi, Jieun
    Ahn, Jaeyoung
    Son, Jung Beom
    Kim, Nam Doo
    CANCER RESEARCH, 2019, 79 (13)
  • [3] Characterisation of CCT251455, a novel, selective and highly potent Mps1 kinase inhibitor
    Faisal, Amir
    Naud, Sebastian
    Schmitt, Jessica
    Westwood, Isaac
    Hayes, Angela
    Gurden, Mark
    Bavetsias, Vassilios
    Berry, Teeara
    Mak, Grace
    Innocenti, Paolo
    Cheung, Jack
    Sheldrake, Peter
    Atrash, Butrus
    Sun, Chongbo
    Matijssen, Berry
    Burke, Rosemary
    Baker, Ross
    McAndrew, Craig
    Rowlands, Martin
    Workman, Paul
    Eccles, Suzanne A.
    Hoelder, Swen
    Raynaud, Florence I.
    vanMontfort, Rob
    Biagg, Julian
    Linardopoulos, Spiros
    CANCER RESEARCH, 2012, 72
  • [4] Discovery of Imidazo[1,2-b]pyridazine Derivatives: Selective and Orally Available Mps1 (TTK) Kinase Inhibitors Exhibiting Remarkable Antiproliferative Activity
    Kusakabe, Ken-ichi
    Ide, Nobuyuki
    Daigo, Yataro
    Itoh, Takeshi
    Yamamoto, Takahiko
    Hashizume, Hiroshi
    Nozu, Kohei
    Yoshida, Hiroshi
    Tadano, Genta
    Tagashira, Sachie
    Higashino, Kenichi
    Okano, Yousuke
    Sato, Yuji
    Inoue, Makiko
    Iguchi, Motofumi
    Kanazawa, Takayuki
    Ishioka, Yukichi
    Dohi, Keiji
    Kido, Yasuto
    Sakamoto, Shingo
    Ando, Shigeru
    Maeda, Masahiro
    Higaki, Masayo
    Baba, Yoshiyasu
    Nakamura, Yusuke
    JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (04) : 1760 - 1775
  • [5] Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy
    Amir Faisal
    Grace W Y Mak
    Mark D Gurden
    Cristina P R Xavier
    Simon J Anderhub
    Paolo Innocenti
    Isaac M Westwood
    Sébastien Naud
    Angela Hayes
    Gary Box
    Melanie R Valenti
    Alexis K De Haven Brandon
    Lisa O'Fee
    Jessica Schmitt
    Hannah L Woodward
    Rosemary Burke
    Rob L M vanMontfort
    Julian Blagg
    Florence I Raynaud
    Suzanne A Eccles
    Swen Hoelder
    Spiros Linardopoulos
    British Journal of Cancer, 2017, 116 : 1166 - 1176
  • [6] Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy
    Faisal, Amir
    Mak, Grace W. Y.
    Gurden, Mark D.
    Xavier, Cristina P. R.
    Anderhub, Simon J.
    Innocenti, Paolo
    Westwood, Isaac M.
    Naud, Sebastien
    Hayes, Angela
    Box, Gary
    Valenti, Melanie R.
    Brandon, Alexis K. De Haven
    O'Fee, Lisa
    Schmitt, Jessica
    Woodward, Hannah L.
    Burke, Rosemary
    vanMontfort, Rob L. M.
    Blagg, Julian
    Raynaud, Florence I.
    Eccles, Suzanne A.
    Hoelder, Swen
    Linardopoulos, Spiros
    BRITISH JOURNAL OF CANCER, 2017, 116 (09) : 1166 - 1176
  • [7] Discovery of Selective and Orally Available Galectin-1 Inhibitors
    Zetterberg, Fredrik R.
    Diehl, Carl
    Hakansson, Maria
    Kahl-Knutson, Barbro
    Leffler, Hakon
    Nilsson, Ulf J.
    Peterson, Kristoffer
    Roper, James A.
    Slack, Robert J.
    JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (24) : 16980 - 16990
  • [8] Discovery of potent, highly selective, and orally bioavailable factor XIa inhibitors for anticoagulant therapy
    Zhang, Yajing
    Huang, Rong
    Hu, Xueqin
    Zheng, Nan
    Geng, Lei
    Yin, Zequn
    Duan, Yajun
    Wang, Qin
    Liao, Chenzhong
    Yang, Xiaoxiao
    Xie, Zhouling
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 289
  • [9] Discovery of DN-016: A highly potent, selective and orally available IDO1 inhibitor for treating cancers
    Chen, Shoujun
    Liu, Fengtao
    Guo, Hongli
    Ren, Shuwen
    Zeng, Yikun
    Yang, Wei
    Qing, Ping
    Chen, Tao
    Zhou, Feng
    Li, Guocheng
    Sun, Mingliang
    Ye, Xiaogang
    Zhang, Xingzhong
    Zhu, Panhu
    Xu, Hui
    Li, Pei
    Li, Donghai
    Jie, Zang
    Li, Huanping
    Zhao, Shuda
    Tan, Jiangjing
    Yang, Heping
    Wang, Longsheng
    Liu, Fang
    Fu, Guangliang
    Du, Jianggang
    Yang, Hongye
    Xue, Wenting
    Wang, Pei
    Guo, Lan
    Wang, Lu
    Li, Qun
    Wang, Yuxun
    Gao, Daxin
    CANCER RESEARCH, 2018, 78 (13)
  • [10] Discovery and optimization of potent, selective, and orally bioavailable Jak1 inhibitors
    Zak, Mark
    Johnson, Adam
    Van Abbema, Anne
    Waszkowycz, Bohdan
    Eigenbrot, Charles
    Chang, Christine
    Hurley, Christopher
    Hanan, Emily
    Kenny, Jane
    Kulagowski, Janusz
    DeVoss, Jason
    Murray, Jeremy
    Balazs, Mercedesz
    Steffek, Micah
    Koehler, Michael
    Ghilardi, Nico
    Chakravarty, Paroma
    Lupardus, Patrick
    Gibbons, Paul
    Dragovich, Peter
    Bergeron, Philippe
    Pulk, Rebecca
    Mendonca, Rohan
    Savage, Scott
    Labadie, Sharada
    Gradl, Stefan
    Ward, Stuart
    Blair, Wade
    Jia, Wei
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243