In Vitro Characterization of a Sustained-Release Formulation for Enfuvirtide

被引：10
|
作者：
Rothstein, Sam N. [1 ]
Huber, Kelly D. [2 ]
Siuis-Cremer, Nicolas [2 ]
Little, Steven R. [1 ,3 ,4 ,5 ,6 ]
机构：
[1] Qrono Inc, Pittsburgh, PA USA
[2] Univ Pittsburgh, Dept Med, Div Infect Dis, Pittsburgh, PA USA
[3] Univ Pittsburgh, Dept Chem Engn, Pittsburgh, PA 15261 USA
[4] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA USA
[5] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA USA
[6] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 03期
关键词：
ERODING POLYMER MATRICES; PREDICTION; HIV-1; MODEL;
D O I：
10.1128/AAC.02440-13
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Although approved by the U.S. Food and Drug Administration, enfuvirtide is rarely used in combination antiretroviral therapies (cART) to treat HIV-1 infection, primarily because of its intense dosing schedule that requires twice-daily subcutaneous injection. Here, we describe the development of enfuvirtide-loaded, degradable poly(lactic-co-glycolic) acid microparticles that provide linear in vitro release of the drug over an 18-day period. This sustained-release formulation could make enfuvirtide more attractive for use in cART.
引用
收藏
页码：1797 / 1799
页数：3
相关论文
共 50 条
  • [21] Sustained-release hydrophilic matrix tablets of zileuton: Formulation and in vitro in vivo studies
    Qiu, YH
    Cheskin, H
    Briskin, J
    Engh, K
    JOURNAL OF CONTROLLED RELEASE, 1997, 45 (03) : 249 - 256
  • [22] Formulation and In vitro Dissolution Characteristics of Sustained-Release Matrix Tablets of Tizanidine Hydrochloride
    Murtaza, Ghulam
    Ullah, Hanif
    Khan, Shujaat Ali
    Mir, Sadullah
    Khan, Abida Kalsoom
    Nasir, Bushra
    Azhar, Saira
    Abid, Mubashir Ali
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2015, 14 (02) : 219 - 225
  • [23] Sustained-release nanoART formulation for the treatment of neuroAIDS
    Jayant, Rahul Dev
    Atluri, Venkata S. R.
    Agudelo, Marisela
    Sagar, Vidya
    Kaushik, Ajeet
    Nair, Madhavan
    International Journal of Nanomedicine, 2015, 10 : 1077 - 1093
  • [24] PHARMACOKINETICS OF A SUSTAINED-RELEASE TRIMAZOSIN TABLET FORMULATION
    FLOUVAT, B
    FODOR, F
    ROUX, A
    BIANCHINE, JR
    AMERICAN HEART JOURNAL, 1983, 106 (05) : 1228 - 1234
  • [25] EVALUATION OF A SUSTAINED-RELEASE FORMULATION OF THE ANTACID ALMAGATE
    WASHINGTON, N
    STEED, KP
    WILSON, CG
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1992, 4 (06) : 495 - 500
  • [26] INVIVO EVALUATION OF A SUSTAINED-RELEASE FORMULATION OF RITODRINE
    VANDERSCHOOT, JB
    PHILIPS, WE
    PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION, 1985, 7 (05) : 227 - 227
  • [27] Formulation Optimization of Paliperidone Sustained-release Pellets
    Zheng, Lin
    Li, Li
    Yin, Gang
    Liao, Ronghui
    Deng, Shengqi
    Tao, Jing
    Chinese Journal of Pharmaceuticals, 2023, 54 (02) : 224 - 229
  • [28] NEW SUSTAINED-RELEASE TABLET FORMULATION OF PROCAINAMIDE
    FREMSTAD, D
    DAHL, S
    JACOBSEN, S
    LUNDE, PKM
    NADLAND, KJ
    MARTHINSEN, AA
    WAALER, T
    LANDMARK, KH
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1973, 6 (04) : 251 - 255
  • [29] THEORETICAL FORMULATION OF SUSTAINED-RELEASE DOSAGE FORMS
    ROBINSON, JR
    ERIKSEN, SP
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1966, 55 (11) : 1254 - &
  • [30] UTILITY OF A SUSTAINED-RELEASE FORMULATION FOR ANTIHYPERTENSIVE THERAPY
    SKAER, TL
    SCLAR, DA
    MARKOWSKI, DJ
    WON, JKH
    JOURNAL OF HUMAN HYPERTENSION, 1993, 7 (05) : 519 - 522
12345