Preparation of microsized spherical aggregates of ultrafine ciprofloxacin particles for dry powder inhalation (DPI)

被引：21
|
作者：
Zhao, Hong [1 ]
Le, Yuan [1 ]
Liu, Haoying [1 ]
Hu, Tingting [1 ]
Shen, Zhigang [1 ,2 ]
Yun, Jimmy [2 ]
Chen, Jian-Feng [1 ]
机构：
[1] Beijing Univ Chem Technol, Minist Educ, Key Lab Nanomat, Sin China Nano Technol Ctr, Beijing 100029, Peoples R China
[2] Nanomat Technol Pte Ltd, Singapore 139944, Singapore
来源：
POWDER TECHNOLOGY | 2009年 / 194卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
Ciprofloxacin; Ultra-fine particles; Reactive precipitation; Fine particle fraction (FPF); Anti-solvent; PULMONARY DELIVERY; DRUGS; NANOPARTICLES; ANTISOLVENT; BUDESONIDE; LUNG;
D O I：
10.1016/j.powtec.2009.03.031
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
In this paper, the ultrafine ciprofloxacin (CPF) particles were prepared by the reactive precipitation of ciprofloxacin hydrochloride (CPF center dot HCI) and NaOH aqueous solution with the presence of isopropyl alcohol (IPA) as the anti-solvent. Subsequently, microsized spherical CPF aggregates were generated using the prepared ultrafine particles as building blocks by spray drying method. The effect of the volume ratio of the CPF solution to anti-solvent (IPA) was investigated. The result shows that the ultra-fined particles of ciprofloxacin can be produced under the volume ratio of 1:15. After spray drying, 3-4 mu m spherical aggregates with ultrafine primary CPF particles can be obtained and exhibited great improved aerosol performance with fine particle fraction (FPF) up to 60%. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：81 / 86
页数：6
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