Evaluation of immunostaining of tumor stem cells in mammary carcinosarcomas and carcinomas in mixed tumors in bitches

被引：0
|
作者：
Magalhaes, Georgia M. [1 ]
Terra, Erika M. [2 ]
Calazans, Sabryna G. [1 ]
Vasconcelos, Rosemeri de O. [2 ]
Alessi, Antonio Carlos [2 ]
机构：
[1] Univ Franca, Hosp Vet, BR-14404600 Franca, Brazil
[2] Univ Estadual Paulista Unesp, Fac Ciencias Agr & Vet, Dept Patol Vet, BR-14884900 Jaboticabal, Brazil
来源：
PESQUISA VETERINARIA BRASILEIRA | 2014年 / 34卷 / 05期
关键词：
CD44; CD24; Oct-4; ALDH-1; mammary neoplasms; diseases of dogs; BREAST-CANCER; IDENTIFICATION; MARKER;
D O I：
10.1590/S0100-736X2014000500012
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Cancer stem cells belong to a small population of cells within the tumor with properties of self-renewal and differentiation into other cell types. In this study, the behavior of both portions, mesenchymal and epithelial, was evaluated. Six carcinosarcomas (CSs), 11 carcinomas within mixed tumors (CWMTs) grade I, 11 grade II, and 10 grade III were evaluated. In the epithelial portions of the CS and CWMTs was observed immunostaining for antibodies CD44, CD24, Oct-4 and ALDH-1. In the mesenchymal portions of the CS, in the epithelial portions of CMTs grades II and III no immunostaining for ALDH-1 was found. It was concluded that the tumor stem cells are expressed in equal proportions in the epithelial and mesenchymal portions of the CS. No immunostaining in the mesenchymal portions of well-differentiated CWMTs was seen.
引用
收藏
页码：455 / 461
页数：7
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