Identification and characterization of murine IRAK-M

被引：39
|
作者：
Rosati, O [1 ]
Martin, MU [1 ]
机构：
[1] Hannover Med Sch, Inst Pharmacol, D-30623 Hannover, Germany
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 293卷 / 05期
关键词：
IRAK-1; IRAK-M; mouse pelle-like-kinase; Toll/IL-1 rcceptor family; IL-1 signal transduction;
D O I：
10.1016/S0006-291X(02)00411-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin-1 receptor-associated-kinases (IRAKs) are signal transduction mediators of the Toll/IL-1 receptor family, which comprise several transmembrane proteins involved in host defense mechanisms. Today four different human IRAKs (hu-IRAK-1, hu-IRAK-2, hu-IRAK-M, hu-IRAK-4) and two murine IRAKs (mouse pelle like kinase (mPLK) and mu-IRAK-4) have been described. Here we report the identification and characterization of murine IRAK-M (mu-IRAK-M), a mouse homologue to human IRAK-M (hu-IRAK-M). These IRAK-M molecules show 71% sequence identity, a comparable cellular expression, and functional similarities with respect to signal transduction capacity and kinase activity, suggesting functional homology in signalling in human and mouse cells. (C) 2002 Elsevier Science (USA). All rights reserved.
引用
收藏
页码：1472 / 1477
页数：6
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