Control of immunoglobulin gene rearrangements in developing B cells

被引：32
|
作者：
Papavasiliou, F
Jankovic, M
Gong, SC
Nussenzweig, MC
机构：
[1] The Lab. of Molecular Immunology, Howard Hughes Med. Inst., R., New York
来源：
CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 02期
关键词：
D O I：
10.1016/S0952-7915(97)80141-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The antigen receptor on B lymphocytes is the product of a series of gene rearrangements which ends when a functional receptor gene is assembled. Recent work has shown that the receptor-associated molecules Ig alpha and Ig beta provide the signals that lead to inhibition of further recombination. Furthermore, Ig beta has been implicated in initiating the last step of the recombination reaction.
引用
收藏
页码：233 / 238
页数：6
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