Mannose binding lectin and prediction of risk for chemotherapy induced febrile neutropenia in patients with a solid tumor

被引：1
|
作者：
Epskamp, Cynthia [1 ]
Goudzwaard, Jeannette A. [2 ]
Fiets, Edward [3 ]
Zuetenhorst, Johanna M. [1 ]
Polee, Marco B. [3 ]
van de Geijn, Gert-Jan M. [4 ]
van Schaik, Ron H. N. [2 ]
Birnie, Erwin [5 ]
Hamberg, Paul [1 ]
机构：
[1] Franciscus Gasthuis, Dept Internal Med, Postbus 10900, NL-3004 BA Rotterdam, Netherlands
[2] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands
[3] Med Ctr Leeuwarden, Dept Internal Med, Leeuwarden, Netherlands
[4] Franciscus Gasthuis, Dept Clin Chem, Rotterdam, Netherlands
[5] Franciscus Gasthuis, Dept Stat & Educ, Rotterdam, Netherlands
来源：
CANCER INVESTIGATION | 2019年 / 37卷 / 03期
关键词：
Mannose-binding lectin (MBL); Solid tumors; Febrile neutropenia; MBL-; genotype; MBL-deficiency; GENE POLYMORPHISMS; SEVERE INFECTIONS; MBL; ASSOCIATION; DEFICIENCY; FICOLINS;
D O I：
10.1080/07357907.2019.1582660
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mannose-binding lectin (MBL) - deficient patients who undergo chemotherapy for a solid tumor might have an increased risk developing febrile neutropenia (FN). We investigated in a prospective cohort study relations between MBL-serum levels and polymorphisms in MBL promotor genotypes (-550H/L and -221X/Y) on incidence and severity of FN. Risk of FN was 17.9% in MBL-deficient and 22.5% in MBL-sufficient patients (RR=0.796, p=0.45). Median MBL serum levels at baseline were respectively 1.39 mu g/mL and 1.09 mu g/mL (p=0.92) in patients with and without FN. In conclusion, serum MBL and MBL genotypes (-550H/L and -221X/Y) do not determine the risk for developing FN.
引用
收藏
页码：156 / 162
页数：7
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