Synthesis of N-Pyridyl Hydroxylamines via Copper-Catalyzed Cross-Coupling

被引：2
|
作者：
Torruellas, Carilyn [1 ]
Hsu, Fu-Lian [1 ]
Walz, Andrew J. [1 ]
机构：
[1] CCDC Chem Biol Ctr, 8198 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA
来源：
SYNTHESIS-STUTTGART | 2019年 / 51卷 / 15期
关键词：
copper; cross-coupling; hydroxylamines; protecting groups; pyridine; DIELS-ALDER; INHIBITORS; DISCOVERY; POTENCY; LIGAND;
D O I：
10.1055/s-0037-1611836
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-Pyridyl hydroxylamine derivatives were prepared via copper-catalyzed cross-coupling of orthogonally functionalized hydroxylamines with iodopyridines. Various amino- and hydroxyl-protecting groups were tolerated. A total of 20 examples were synthesized in 28-90% yield.
引用
收藏
页码：2891 / 2896
页数：6
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