Synthesis of Substituted 5-(1,2,4-Oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thiones

被引：7
|
作者：
Kharchenko, Juliya V. [1 ]
Detistov, Oleksandr S. [1 ]
Orlov, Valeriy D. [1 ]
机构：
[1] Kharkov Natl Univ, Dept Chem, UA-61077 Kharkov, Ukraine
来源：
JOURNAL OF COMBINATORIAL CHEMISTRY | 2009年 / 11卷 / 02期
关键词：
ONE-POT SYNTHESIS; OXADIAZOLES; RECEPTOR; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; CATALYST; AGONISTS;
D O I：
10.1021/cc800111h
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We have developed a liquid-phase route for combinatorial synthesis of novel substituted 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thiones. Biginelli-type three-component condensation of 1-(3-aryl-1,2,4-oxadiazol-5-yl)acetones, thiourea, and benzaldehydes is shown to result in new 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thione heterocyclic system. If salicylaldehydes are used in this reaction, a mixture of 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thiones and 11-(1,2,4-oxadiazol-5-yl)-2,3,5,6-tetrahydro-4H-2,6-methano-1,3,5-benzoxadiazocine-4-thiones is formed.
引用
收藏
页码：216 / 219
页数：4
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