Genetic influences in the aetiology of tears of the rotator cuff - Sibling risk of a full-thickness tear

被引:103
|
作者
Harvie, P [1 ]
Ostlere, SJ [1 ]
Teh, J [1 ]
McNally, EG [1 ]
Clipsham, K [1 ]
Burston, BJ [1 ]
Pollard, TCB [1 ]
Carr, AJ [1 ]
机构
[1] Univ Oxford, Nuffield Dept Orthopaed Surg, Nuffield Orthopaed Ctr, Oxford OX3 7LD, England
来源
关键词
D O I
10.1302/0301-620X.86B5.14747
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
From a retrospective, cohort study of 205 patients diagnosed with full-thickness tears of the rotator cuff, we determined, using ultrasound, the prevalence of such tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full-thickness tears in siblings versus controls was 2.42 (95% CI 1.77 to 3.31). The relative risk of symptomatic full-thickness tears in siblings versus controls was 4.65 (95% CI 2.42 to 8.63). The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full-thickness tears of the rotator cuff.
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页码:696 / 700
页数:5
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