Efficient solution phase parallel synthesis of norstatine analogs

被引：11

作者：

Voronkov, MV

Gontcharov, AV

Wang, ZM

Richardson, PF

Kolb, HC

机构：

[1] Lexicon Pharmaceut, Med Chem, Princeton, NJ 08540 USA

[2] Wyeth Res, Pearl River, NY 10965 USA

[3] Rhodia Chirex, Boston, MA 02129 USA

[4] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

TETRAHEDRON | 2004年 / 60卷 / 41期

关键词：

epoxide; nitrile; norstatine; solution phase combinatorial chemistry;

D O I：

10.1016/j.tet.2004.07.085

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of glycidic amides with various functionalized nitriles to afford norstatine analogs in a regio- and diastereoselective fashion (43-99% yield) is described. Utilizing this chemistry, a 20 membered solution phase library was prepared in two steps featuring three points of diversity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：9043 / 9048

页数：6

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