Synthesis and biological activities of some thiazolidin-4-ones

被引：0

作者：

Ozadah, Keriman

Ozkanh, Fugen ^{[1
]}

Erol, Dilek

Dogan, Ali Evrim

Erol, Kevser

机构：

[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey

[2] Yeditepe Univ, Fac Pharm, Istanbul, Turkey

[3] Osman Gazi Univ, Fac Med, Dept Pharmacol, Eskisehir, Turkey

来源：

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 2006年 / 56卷 / 10期

关键词：

antihistaminic agents; thiazolidin-4-ones; anticholinergic activity; antihistaminic activity; synthesis;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this study, fifteen 2,3-disubstituted-4-thiazolidinone derivatives were synthesized by the reaction of Schiff bases and a-mercaptoacetic acid. The structures of the compounds were elucidated by IR, H-1-NMR, C-13-NMR, mass spectral data and elementary analysis. The antihist-aminic and anticholinergic activities of the compounds were determined by tests performed on isolated guinea pig trachea in comparison with aminophylline (CAS 317-34-0). Compound 15 (3-[3-(2-methyl-piperidine-1-yl)propyl]-2-(4-methyl- phenyl)thiazolidin-4-one hydrochloride) showed the highest inhibition (53%).

引用

页码：678 / 681

页数：4

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