Synthesis and biological activities of some thiazolidin-4-ones

被引：0
|
作者：
Ozadah, Keriman
Ozkanh, Fugen [1 ]
Erol, Dilek
Dogan, Ali Evrim
Erol, Kevser
机构：
[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey
[2] Yeditepe Univ, Fac Pharm, Istanbul, Turkey
[3] Osman Gazi Univ, Fac Med, Dept Pharmacol, Eskisehir, Turkey
来源：
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 2006年 / 56卷 / 10期
关键词：
antihistaminic agents; thiazolidin-4-ones; anticholinergic activity; antihistaminic activity; synthesis;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this study, fifteen 2,3-disubstituted-4-thiazolidinone derivatives were synthesized by the reaction of Schiff bases and a-mercaptoacetic acid. The structures of the compounds were elucidated by IR, H-1-NMR, C-13-NMR, mass spectral data and elementary analysis. The antihist-aminic and anticholinergic activities of the compounds were determined by tests performed on isolated guinea pig trachea in comparison with aminophylline (CAS 317-34-0). Compound 15 (3-[3-(2-methyl-piperidine-1-yl)propyl]-2-(4-methyl- phenyl)thiazolidin-4-one hydrochloride) showed the highest inhibition (53%).
引用
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页码：678 / 681
页数：4
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