Antifungal effect of amentoflavone derived from Selaginella tamariscina

被引：69
|
作者：
Jung, Hyun Jun
Sung, Woo Sang
Yeo, Soo-Hwan
Kim, Hyun Soo
Lee, In-Seon
Woo, Eun-Rhan
Lee, Dong Gun [1 ]
机构：
[1] Kyungpook Natl Univ, Coll Nat Sci, Dept Microbiol, Taegu 702701, South Korea
[2] Kyungpook Natl Univ, Agrobiotechnol Educ Ctr, Taegu 702701, South Korea
[3] Keimyung Univ, Ctr Tradit Microorg Resources, TMR, Taegu 704701, South Korea
[4] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2006年 / 29卷 / 09期
关键词：
biflavonoid; amentoflavone; antifungal activity; dimorphic transition;
D O I：
10.1007/BF02974074
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Amentoflavone is a plant biflavonoid that was isolated from an ethyl acetate extract of the whole plant of Selaginella tamariscina (Beauv.) spring. 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC were used to determine its structure. Amentoflavone exhibited potent antifungal activity against several pathogenic fungal strains but had a very low hemolytic effect on human erythrocytes. In particular, amentoflavone induced the accumulation of intracellular trehalose on C. albicans as a stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae during pathogenesis. In conclusion, amentoflavone has great potential to be a lead compound for the development of antifungal agents.
引用
收藏
页码：746 / 751
页数：6
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