N-Acetyltransferase 2 Genotypes Are Associated With Diisocyanate-Induced Asthma

被引:10
|
作者
Yucesoy, Berran [1 ]
Kissling, Grace E. [2 ]
Johnson, Victor J. [3 ]
Lummus, Zana L. [1 ]
Gautrin, Denyse [4 ]
Cartier, Andre [4 ]
Boulet, Louis-Philippe [5 ]
Sastre, Joaquin [6 ,7 ]
Quirce, Santiago [7 ,8 ]
Tarlo, Susan M. [9 ,10 ]
Cruz, Maria-Jesus [7 ,11 ]
Munoz, Xavier [7 ,11 ]
Luster, Michael I. [12 ]
Bernstein, David I. [1 ]
机构
[1] Univ Cincinnati, Div Immunol Allergy & Rheumatol, Cincinnati, OH 45267 USA
[2] NIEHS, NIH, Res Triangle Pk, NC 27709 USA
[3] BRT Burleson Res Technol, Morrisville, NY USA
[4] Univ Montreal, Hop Sacre Coeur Montreal, Montreal, PQ, Canada
[5] Univ Laval, Hop Laval, Ste Foy, PQ G1K 7P4, Canada
[6] Fdn Jimenez Diaz, Dept Allergy, E-28040 Madrid, Spain
[7] CIBER Enfermedades Resp CIBERES, Madrid, Spain
[8] Hosp La Paz IdiPAZ, Dept Allergy, Madrid, Spain
[9] Univ Toronto, Dept Med, Toronto, ON M5S 1A1, Canada
[10] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON M5S 1A1, Canada
[11] Hosp Valle De Hebron, Barcelona, Spain
[12] W Virginia Univ, Sch Publ Hlth, Morgantown, WV 26506 USA
关键词
OCCUPATIONAL ASTHMA; TOLUENE DIISOCYANATE; MOLECULAR-GENETICS; EPITHELIAL-CELLS; BRONCHIAL-ASTHMA; EXPOSURE; ACETYLATION; RISK; NAT2; POLYMORPHISMS;
D O I
10.1097/JOM.0000000000000561
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objective: To investigate whether genetic variants of N-acetyltransferase (NAT) genes are associated with diisocyanate asthma (DA). Methods: The study population consisted of 354 diisocyanate-exposed workers. Genotyping was performed using a 50-nuclease polymerase chain reaction assay. Results: The NAT2 rs2410556 and NAT2 rs4271002 variants were significantly associated with DA in the univariate analysis. In the first logistic regression model comparing DA_ and asymptomatic worker groups, the rs2410556 (P = 0.004) and rs4271002 (P < 0.001) single nucleotide polymorphisms and the genotype combination, NAT2 rs4271002*NAT1 rs11777998, showed associations with DA risk (P - 0.014). In the second model comparing DA+ and DA- groups, NAT2 rs4271002 variant and the combined genotype, NAT1 rs8190845*NAT2 rs13277605, were significantly associated with DA risk (P = 0.022, P = 0.036, respectively). Conclusions: These findings suggest that variations in the NAT2 gene and their interactions contribute to DA susceptibility.
引用
收藏
页码:1331 / 1336
页数:6
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