Tabernaesines A-I, Cytotoxic Aspidosperma-Aspidosperma-Type Bisindole Alkaloids from Tabernaemontana pachysiphon

被引：23

作者：

Yi, Wen-Fang ^{[1
]}

Ding, Xiao ^{[1
]}

Chen, Yuan-Zhi ^{[1
]}

Adelakun, Tiwalade A. ^{[1
]}

Zhang, Yu ^{[1
]}

Hao, Xiao-Jiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2020年 / 83卷 / 11期

关键词：

BIS-INDOLINE ALKALOIDS; VOACANGA; SUBSTANCES;

D O I：

10.1021/acs.jnatprod.9b00768

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Twenty-one aspidosperma-aspidosperma alkaloids, including the new tabernaesines A-J (1-9), were obtained from Tabernaemontana pachysiphon. The structures and absolute configurations were elucidated using HRMS and NMR experiments. Compounds 1-9 possessed a rare spiro heterocycle moiety between the monomeric units, while compounds 4 and 5 were characterized by an indole ring fused with an (N,N-diethyl)methyl amino group. Compounds 1, 5-7, 15, and 16 exhibited moderate cytotoxic potency against various human cancer cell lines at IC50 2.5-9.8 mu M.

引用

页码：3215 / 3222

页数：8

共 35 条

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