Gold/Copper-Co-catalyzed Tandem Reactions of 2-Alkynylanilines: A Synthetic Strategy for the C2-Quaternary Indolin-3-ones

被引：54

作者：

Li, Yi-Jin ^{[1
]}

Yan, Na ^{[1
]}

Liu, Chun-Hua ^{[1
]}

Yu, Yang ^{[1
]}

Zhao, Yu-Long ^{[1
]}

机构：

[1] Northeast Normal Univ, Fac Chem, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Changchun 130024, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 05期

关键词：

AEROBIC OXYGENATION; EFFICIENT SYNTHESIS; INDOLE ALKALOIDS; REARRANGEMENT; CASCADE; CONCISE; DERIVATIVES; OXIDATION; ACCESS; ROUTE;

D O I：

10.1021/acs.orglett.7b00200

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new strategy for direct and highly efficient synthesis of 2,3'-bisindolin-3-ones has been developed via a gold/copper-co-catalyzed tandem reactions of 2-alkynylanilines using TBHP as the terminal oxidant and oxygen-atom source. The single-step process involves a novel tandem intermolecular nucleophilic addition, intramolecular cyclization/oxidative cross-dehydrogenative coupling where up to four new bonds and two indole rings were created simultaneously in one-pot manner. The reaction features a broad substrate scope, good functional group tolerance, and high atom-economy.

引用

页码：1160 / 1163

页数：4

共 45 条

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