Erenumab (AMG 334), an antagonist of the Canonical Calcitonin Gene-Related Peptide Receptor, does not impair vasodilatory or contractile responses to other agents in human isolated cerebral arteries

被引：0
|
作者：
Ohlsson, Lena [1 ]
Haanes, Kristian A. [2 ]
Kronvall, Erik [3 ]
Xu, Cen [4 ]
Snellman, Josefin [5 ]
Edvinsson, Lars [1 ]
机构：
[1] Dept Clin Sci, Med, Lund, Sweden
[2] Glostrup Res Inst, Dept Clin Expt Res, Glostrup, Denmark
[3] Lund Univ Hosp, Dept Neurosurg, Lund, Sweden
[4] Amgen Inc, Thousand Oaks, CA 91320 USA
[5] Novartis Pharma AG, Novartis, Basel, Switzerland
来源：
CEPHALALGIA | 2019年 / 39卷
关键词：
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
IHC-PO-141
引用
收藏
页码：213 / 214
页数：2
相关论文
共 47 条
  • [31] The calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS blocks CGRP and adrenomedullin vasoactive responses in the microvasculature
    Grant, AD
    Tam, CW
    Lazar, Z
    Shih, MK
    Brain, SD
    BRITISH JOURNAL OF PHARMACOLOGY, 2004, 142 (07) : 1091 - 1098
  • [32] A phase IV clinical trial of gastrointestinal motility in adult patients with migraine before and after initiation of a calcitonin gene-related peptide ligand (galcanezumab) or receptor (erenumab) antagonist
    Kudrow, David
    Nguyen, Linda
    Semler, Jack
    Stroud, Chad
    Samaan, Karen
    Hoban, Deirdre B.
    Wietecha, Linda
    Hsu, Hai-An
    Pearlman, Eric
    HEADACHE, 2022, 62 (09): : 1164 - 1176
  • [33] Calcitonin Gene-Related peptide receptor antagonist suppresses allergic asthma responses via downregulation of group 2 innate lymphoid cells in mice
    Ike, Erina
    Kawano, Tasuku
    Takahashi, Kento
    Miyasaka, Tomomitsu
    Takahashi, Tomoko
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 122
  • [34] Volatile anesthetics inhibit calcitonin gene-related peptide receptor-mediated responses in pithed rats and human neuroblastoma cells
    Kuroda, M
    Yoshikawa, D
    Nishikawa, K
    Saito, S
    Goto, F
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 311 (03): : 1016 - 1022
  • [35] Prevention of Episodic Migraine with AMG 334, a Human Anti-Calcitonin Gene-Related Peptide Receptor Monoclonal Antibody: Phase 2 Study Results and 52-Week Analysis of Open-Label Extension
    Lenz, Robert
    Dodick, David
    Goadsby, Peter
    Silberstein, Stephen
    Reuter, Uwe
    Ashina, Messoud
    Saper, Joel
    Cady, Roger
    Zhang, Feng
    Trotman, Marie-Louise
    Dietrich, Julie
    Sun, Hong
    NEUROLOGY, 2016, 86
  • [36] Calcitonin gene-related peptide-induced vasodilation in the human forearm:: inhibition by the CGRP-receptor antagonist CGRP8-37
    Vanmolkot, FHM
    De Hoon, JNJM
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2004, 57 (03) : 368 - 368
  • [37] DISTRIBUTION AND EFFECTS OF NEUROPEPTIDE-Y, VASOACTIVE-INTESTINAL-PEPTIDE, SUBSTANCE-P, AND CALCITONIN GENE-RELATED PEPTIDE IN HUMAN MIDDLE MENINGEAL ARTERIES - COMPARISON WITH CEREBRAL AND TEMPORAL ARTERIES
    JANSEN, I
    UDDMAN, R
    EKMAN, R
    OLESEN, J
    OTTOSSON, A
    EDVINSSON, L
    PEPTIDES, 1992, 13 (03) : 527 - 536
  • [38] Preparing Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist [18F]Ubrogepant to Enable Biodistribution Studies in Non-Human Primate
    Fan, Kuo-Hsien
    Skaddan, Marc
    Voorbach, Martin
    Comley, Robert
    Finnema, Sjoerd
    NUCLEAR MEDICINE AND BIOLOGY, 2023, 126 : S34 - S35
  • [39] Calcitonin gene-related peptide is released from capsaicin-sensitive nerve fibres and induces vasodilatation of human cerebral arteries concomitant with activation of adenylyl cyclase
    JansenOlesen, I
    Mortensen, A
    Edvinsson, L
    CEPHALALGIA, 1996, 16 (05) : 310 - 316
  • [40] A potent and selective calcitonin gene-related peptide (CGRP) receptor antagonist, MK-8825, inhibits responses to nociceptive trigeminal activation: Role of CGRP in orofacial pain
    Romero-Reyes, Marcela
    Pardi, Vanessa
    Akerman, Simon
    EXPERIMENTAL NEUROLOGY, 2015, 271 : 95 - 103
12345