APOBEC3H polymorphisms and susceptibility to HIV-1 infection in an Indian population

被引：14
|
作者：
Naruse, Taeko K. [1 ]
Sakurai, Daisuke [1 ]
Ohtani, Hitoshi [1 ]
Sharma, Gaurav [2 ]
Sharma, Surendra K. [3 ]
Vajpayee, Madhu [4 ]
Mehra, Narinder K. [2 ]
Kaur, Gurvinder [2 ]
Kimura, Akinori [1 ]
机构：
[1] TMDU, Med Res Inst, Dept Mol Pathogenesis, Tokyo, Japan
[2] All India Inst Med Sci, Dept Transplant Immunol & Immunogenet, New Delhi, India
[3] All India Inst Med Sci, Dept Med, New Delhi 110029, India
[4] All India Inst Med Sci, Dept Microbiol, New Delhi 110029, India
来源：
JOURNAL OF HUMAN GENETICS | 2016年 / 61卷 / 03期
基金：
日本学术振兴会;
关键词：
VARIANTS; PROGRESSION; DETERMINES; HAPLOTYPE; AIDS; VIF;
D O I：
10.1038/jhg.2015.136
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Human APOBEC3H (A3H) is a member of APOBEC cytidine deaminase family intensively constraining the HIV-1 replication. A3H is known to be polymorphic with different protein stability and anti-HIV-1 activity in vitro. We recently reported that A3H haplotypes composed of two functional polymorphisms, rs139292 (N15del) and rs139297 (G105R), were associated with the susceptibility to HIV-1 infection in Japanese. To confirm the association of A3H and HIV-1 infection in another ethnic group, a total of 241 HIV-1-infected Indian individuals and ethnic-matched 286 healthy controls were analyzed for the A3H polymorphisms. The frequency of 15del allele was high in the HIV-1-infected subjects as compared with the controls (0.477 vs 0.402, odds ratio (OR)=1.36, P=0.014). Haplotype analysis showed that the frequencies of 15del-105R was high (0.475 vs 0.400, OR=1.36, permutation P=0.037) in the HIV-1-infected subjects, confirming the association of A3H polymorphisms with the susceptibility to HIV-1 infection.
引用
收藏
页码：263 / 265
页数：3
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