OPINION Challenges in circulating tumour cell research

被引：836

作者：

Alix-Panabieres, Catherine ^{[1
,2
]}

Pantel, Klaus ^{[3
]}

机构：

[1] Univ Med Ctr, Lab Rare Human Circulating Cells, Dept Cellular & Tissular Biopathol Tumors, Saint Eloi Hosp,Inst Med Regenerat & Biotherapy, F-34295 Montpellier 5, France

[2] Univ Inst Clin Res, Epidemiol Biostat & Publ Hlth UM1 EA2415, F-34093 Montpellier 5, France

[3] Univ Med Ctr, Dept Tumor Biol, D-20246 Hamburg, Germany

来源：

NATURE REVIEWS CANCER | 2014年 / 14卷 / 09期

基金：

欧洲研究理事会;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; METASTATIC BREAST-CANCER; RESISTANT PROSTATE-CANCER; POLYMERASE-CHAIN-REACTION; PERIPHERAL-BLOOD; CLINICAL-SIGNIFICANCE; BIOLOGICAL INSIGHTS; CHEMOKINE RECEPTORS; PROGENITOR CELLS; LIQUID BIOPSY;

D O I：

10.1038/nrc3820

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

During the past ten years, circulating tumour cells (CTCs) have received enormous attention as new biomarkers and the subject of basic research. Although CTCs are already used in numerous clinical trials, their clinical utility is still under investigation. Many issues regarding the detection and characterization of CTCs remain unknown. In this Opinion article, we propose a conceptual framework of CTC assays and point out current challenges of CTC research, which might structure this dynamic field of translational cancer research.

引用

页码：623 / 631

页数：9

共 50 条

[21] Detection of circulating tumour cell clusters in human glioblastoma
Krol, Ilona
Castro-Giner, Francesc
Maurer, Martina
Gkountela, Sofia
Szczerba, Barbara Maria
Scherrer, Ramona
Coleman, Niamh
Carreira, Suzanne
Bachmann, Felix
Anderson, Stephanie
Engelhardt, Marc
Lane, Heidi
Evans, Thomas Ronald Jeffry
Plummer, Ruth
Kristeleit, Rebecca
Lopez, Juanita
Aceto, Nicola
BRITISH JOURNAL OF CANCER, 2018, 119 (04) : 487 - 491
[22] Circulating tumour cell (CTC) analysis in radiotherapy patients
Hudson, A.
RADIOTHERAPY AND ONCOLOGY, 2018, 127 : S60 - S60
[23] Method validation of circulating tumour cell enumeration at low cell counts
Jeffrey Cummings
Karen Morris
Cong Zhou
Robert Sloane
Matt Lancashire
Daniel Morris
Stephen Bramley
Matt Krebs
Leila Khoja
Caroline Dive
BMC Cancer, 13
[24] Method validation of circulating tumour cell enumeration at low cell counts
Cummings, Jeffrey
Morris, Karen
Zhou, Cong
Sloane, Robert
Lancashire, Matt
Morris, Daniel
Bramley, Stephen
Krebs, Matt
Khoja, Leila
Dive, Caroline
BMC CANCER, 2013, 13
[25] Unravelling the biological and clinical challenges of circulating tumour cells in epithelial ovarian carcinoma
Lewis, Faye
Beirne, James
Henderson, Brian
Norris, Lucy
Cadoo, Karen
Kelly, Tanya
Martin, Cara
Hurley, Sinead
Kanjuga, Marika
O'Driscoll, Lorraine
Gately, Kathy
Oner, Ezgi
Saini, Volga M.
Brooks, Doug
Selemidis, Stavros
Kamran, Waseem
Haughey, Niamh
Maguire, Patrick
O'Gorman, Catherine
Abu Saadeh, Feras
Ward, Mark P.
O'Leary, John J.
O'Toole, Sharon A.
CANCER LETTERS, 2024, 605
[26] Clinical Applications of Circulating Tumour Cells and Circulating Tumour DNA in Non-Small Cell Lung Cancer-An Update
Kapeleris, Joanna
Ebrahimi Warkiani, Majid
Kulasinghe, Arutha
Vela, Ian
Kenny, Liz
Ladwa, Rahul
O'Byrne, Kenneth
Punyadeera, Chamindie
FRONTIERS IN ONCOLOGY, 2022, 12
[27] THE DIAGNOSIS OF MALIGNANT PANCREATIC TUMOURS BY CIRCULATING TUMOUR CELL DETECTION
Basile, P.
Iwanicki-Caron, I.
Toure, E.
Antonietti, M.
Lecleire, S.
Di Fiore, F.
Sabourin, J. C.
Michel, P.
ANNALS OF ONCOLOGY, 2012, 23 : 252 - 253
[28] Circulating Cell-Free Tumour DNA in the Management of Cancer
Francis, Glenn
Stein, Sandra
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (06) : 14122 - 14142
[29] Circulating tumor cell clusters: Insights into tumour dissemination and metastasis
Herath, Sayuri
Razavi Bazaz, Sajad
Monkman, James
Ebrahimi Warkiani, Majid
Richard, Derek
O'Byrne, Ken
Kulasinghe, Arutha
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2020, 20 (11) : 1139 - 1147
[30] In vivo detection of circulating tumour cell clusters by photodiagnostic spectroscopy
Schikora, Detlef
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2020, 30

← 1 2 3 4 5 →