Relationship of adiponectin and its multimers to metabolic indices in cats during weight change

被引：13
|
作者：
Witzel, A. L. [1 ]
Kirk, C. A. [1 ]
Kania, S. A. [2 ]
Bartges, J. W. [1 ]
Boston, R. C. [3 ]
Moyers, T. [1 ]
Byrd, H. [1 ]
Lauten, S. [1 ]
机构：
[1] Univ Tennessee, Coll Vet Med, Dept Small Anim Clin Sci, Knoxville, TN 37996 USA
[2] Univ Tennessee, Coll Vet Med, Dept Biomed & Diagnost Sci, Knoxville, TN 37996 USA
[3] Univ Penn, Dept Clin Studies, New Bolton Ctr, Sch Vet Med, Philadelphia, PA 19104 USA
来源：
DOMESTIC ANIMAL ENDOCRINOLOGY | 2015年 / 53卷
关键词：
Feline; Adiponectin; Leptin; Cat; Adipokine; PLASMA LEPTIN CONCENTRATIONS; INSULIN SENSITIVITY; GLUCOSE-METABOLISM; MINIMAL MODEL; OBESE CATS; FAT MASS; RESISTANCE; IMPROVEMENT; EXPRESSION; INDICATORS;
D O I：
10.1016/j.domaniend.2015.05.001
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Adiponectin is an important anti-inflammatory hormone secreted from adipose tissue. The high-molecular-weight form of adiponectin (HMW) closely correlates with insulin sensitivity in human beings. This study uses a novel method of size-exclusion gel chromatography combined with enzyme-linked immunosorbent assay to measure HMW feline adiponectin and determine its relationship to leptin, cholesterol, and insulin sensitivity as cats gain and lose weight. In addition, total adiponectin and its messenger RNA expression in subcutaneous adipose tissue were measured. No correlations were found between total serum adiponectin and subcutaneous adipose messenger RNA expression, fat mass, or measures of insulin sensitivity. This study demonstrates that cats have high percentages of HMW adiponectin. Although weak correlations between HMW adiponectin and fat mass were detected, additional cats are needed to determine if the correlations are significant. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：70 / 77
页数：8
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