Orthogonal near-infrared upconversion co-regulated site-specific O2 delivery and photodynamic therapy for hypoxia tumor by using red blood cell microcarriers

被引：139

作者：

Wang, Peiyuan ^{[1
]}

Li, Xiaomin ^{[1
]}

Yao, Chi ^{[1
]}

Wang, Wenxing ^{[1
]}

Zhao, Mengyao ^{[1
]}

El-Toni, Ahmed Mohamed ^{[2
,3
]}

Zhang, Fan ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem, Collaborat Innovat Ctr Chem Energy Mat, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China

[2] King Saud Univ, King Abdullah Inst Nanotechnol, Riyadh 11451, Saudi Arabia

[3] CMRDI, Cairo 11421, Egypt

来源：

BIOMATERIALS | 2017年 / 125卷

基金：

中国博士后科学基金;

关键词：

Upconversion; Hypoxia; Biological barriers; Photodynamic therapy; NANOPARTICLES; CANCER; OXYGEN; RADIOTHERAPY; ENHANCE; GROWTH; ERYTHROCYTES; ANGIOGENESIS; VASCULATURE; RESISTANCE;

D O I：

10.1016/j.biomaterials.2017.02.017

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Pre-existing hypoxia in tumors can result in an inadequate oxygen supply during photodynamic therapy (PDT), which in turn hampers photodynamic efficacy. To overcome this problem, we developed an orthogonal near-infrared upconversion controlled red blood cell (RBC) microcarriers to selectively deliver 02 in hypoxia area. Moreover, this RBC microcarriers are able to overcome a series of complex biological barriers which include transporting across the inflamed endothelium, evading mononuclear phagocyte system, reducing reticuloendothelial system uptake. Based on these abilities, RBC microcarriers have efficient tumors accumulation and are capable of delivery a large amount of O-2 for PDT under near infrared (NIR) irradiation to realize effective solid tumor eradication. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：90 / 100

页数：11

共 4 条

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