Theoretical conformational analysis of tetrapeptide Ac-Cys-Pro-Gly-Cys-NHMe with disulfide linkage

被引：4
|
作者：
Yoshimoto, J
Nishinaga, A
Oka, M
Hayashi, T
机构：
[1] NAGOYA UNIV,GRAD SCH HUMAN INFORMAT,CHIKUSA KU,NAGOYA,AICHI 46401,JAPAN
[2] OSAKA INST TECHNOL,DEPT APPL CHEM,ASAHI KU,OSAKA 535,JAPAN
[3] UNIV OSAKA PREFECTURE,ADV SCI & TECHNOL RES INST,SAKAI,OSAKA 593,JAPAN
来源：
POLYMER BULLETIN | 1997年 / 38卷 / 01期
关键词：
D O I：
10.1007/s002890050026
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Theoretical conformational analysis was carried out for the acyclic and cyclic tetrapeptides Ac-Cys-Pro-Gly-Cys-NHMe using ECEPP and optimization procedure for investigating the conformational preference of peptides having disulfide linkage. Calculated results indicate that cyclic Ac-Cys-Pro-Gly-Cys-NHMe forms compactly fold conformations with type II beta-bend at the Pro-Gly portion, and also show fairly good agreement with experimental results of the NMR spectroscopy for the tetrapeptides having Cys-Pro-Gly-Cys sequence.
引用
收藏
页码：109 / 115
页数：7
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  • [21] THEORETICAL ANALYSIS OF CONFORMATIONS OF AC-GLY-L-ALA-GLY-NHME WITH INTRAMOLECULAR HYDROGEN-BONDS
    PLETNEV, VZ
    KADYMOVA, FA
    POPOV, EM
    [J]. BIOPOLYMERS, 1974, 13 (06) : 1085 - 1092
  • [22] CONFORMATIONAL-ANALYSIS OF THE TETRAPEPTIDE PRO-D-PHE-PRO-GLY IN AQUEOUS-SOLUTION
    HUBNER, D
    HARTRODT, B
    KLEINPETER, E
    STROHL, D
    BRANDT, W
    SCHINKE, H
    WAHAB, M
    FISCHER, G
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 177 (01) : 271 - 278
  • [23] Conformational analysis of small peptides of the type Ac-X-NHMe, where X = Gly, Ala, Aib and Cage
    Bisetty, K
    Catalan, JG
    Kruger, H
    Perez, JJ
    [J]. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 2005, 731 (1-3): : 127 - 137
  • [24] Conformational investigation of α,β-dehydropeptides.: XVI.: β-turn tendency in Ac-Pro-ΔXaa-NHMe:: crystallographic and theoretical studies
    Broda, Malgorzata A.
    Ciszak, Ewa M.
    Koziol, Anna E.
    Pietrzynski, Grzegorz
    Rzeszotarska, Barbara
    [J]. JOURNAL OF PEPTIDE SCIENCE, 2006, 12 (08) : 538 - 549
  • [25] THEORETICAL CONFORMATIONAL-ANALYSIS OF POLY(VAL-PRO-GLY-GLY) WITH CIS-PEPTIDE BOND AT VAL-PRO PORTION
    OKA, M
    BABA, Y
    KAGEMOTO, A
    NAKAJIMA, A
    [J]. POLYMER BULLETIN, 1991, 25 (01) : 87 - 94
  • [26] CHAIN-FOLDING INITIATION STRUCTURES IN RIBONUCLEASE-A - CONFORMATIONAL-ANALYSIS OF TRANS-AC-ASN-PRO-TYR-NHME AND TRANS-AC-TYR-PRO-ASN-NHME IN WATER AND IN THE SOLID-STATE
    MONTELIONE, GT
    ARNOLD, E
    MEINWALD, YC
    STIMSON, ER
    DENTON, JB
    HUANG, SG
    CLARDY, J
    SCHERAGA, HA
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (25) : 7946 - 7958
  • [27] CONFORMATIONAL STUDY OF CYCLO(1,5)-AC-PEN-ARG-GLY-ASP-CYS-NH2 IN WATER BY NMR AND MOLECULAR-DYNAMICS
    SIAHAAN, TJ
    CHAKRABARTI, S
    VANDERVELDE, D
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 187 (02) : 1042 - 1047
  • [28] CONFORMATIONAL-ANALYSIS OF SMALL DISULFIDE LOOPS - SPECTROSCOPIC AND THEORETICAL-STUDIES ON A SYNTHETIC CYCLIC TETRAPEPTIDE CONTAINING CYSTINE
    VENKATACHALAPATHI, YV
    PRASAD, BVV
    BALARAM, P
    [J]. BIOCHEMISTRY, 1982, 21 (22) : 5502 - 5509
  • [29] CONFORMATIONAL ENERGY ANALYSIS OF THE PENTAPEPTIDE AC-ARG-ASN-CYS-TYR-ASN-NMA FROM ALPHA-1-PUROTHIONIN
    FELLER, DC
    ZIMMERMAN, SS
    VERNON, LP
    [J]. INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1989, 34 (06): : 487 - 491
  • [30] THEORETICAL-ANALYSIS OF AC-L-ALA-L-PRO-L-ALA-NHME CONFORMATIONS WITH INTRAMOLECULAR HYDROGEN-BONDS
    GROMOV, EP
    PLETNEV, VZ
    [J]. KHIMIYA PRIRODNYKH SOEDINENII, 1976, (02): : 233 - 238
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