Theoretical conformational analysis of tetrapeptide Ac-Cys-Pro-Gly-Cys-NHMe with disulfide linkage

被引：4
|
作者：
Yoshimoto, J
Nishinaga, A
Oka, M
Hayashi, T
机构：
[1] NAGOYA UNIV,GRAD SCH HUMAN INFORMAT,CHIKUSA KU,NAGOYA,AICHI 46401,JAPAN
[2] OSAKA INST TECHNOL,DEPT APPL CHEM,ASAHI KU,OSAKA 535,JAPAN
[3] UNIV OSAKA PREFECTURE,ADV SCI & TECHNOL RES INST,SAKAI,OSAKA 593,JAPAN
来源：
POLYMER BULLETIN | 1997年 / 38卷 / 01期
关键词：
D O I：
10.1007/s002890050026
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Theoretical conformational analysis was carried out for the acyclic and cyclic tetrapeptides Ac-Cys-Pro-Gly-Cys-NHMe using ECEPP and optimization procedure for investigating the conformational preference of peptides having disulfide linkage. Calculated results indicate that cyclic Ac-Cys-Pro-Gly-Cys-NHMe forms compactly fold conformations with type II beta-bend at the Pro-Gly portion, and also show fairly good agreement with experimental results of the NMR spectroscopy for the tetrapeptides having Cys-Pro-Gly-Cys sequence.
引用
收藏
页码：109 / 115
页数：7
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