Anticancer s-Triazine Derivatives: A Synthetic Attribute

被引：8

作者：

Jain, Sonika ^{[1
]}

Jain, Pankaj Kumar ^{[2
]}

Sain, Shalu ^{[1
]}

Kishore, Dharma ^{[1
]}

Dwivedi, Jaya ^{[1
]}

机构：

[1] Banasthali Vidyapith, Dept Chem, Banasthali 304022, India

[2] Banasthali Vidyapith, Dept Pharm, Banasthali 304022, India

来源：

MINI-REVIEWS IN ORGANIC CHEMISTRY | 2020年 / 17卷 / 08期

关键词：

1,3,5-Triazines; anticancer; synthesis; Suzuki cross-coupling; arylmethylamin motifs; ZSTK474; BIOLOGICAL EVALUATION; 1,3,5-TRIAZINE DERIVATIVES; INHIBITORS OPTIMIZATION; ANTITUMOR EVALUATION; HSP90; INHIBITOR; DESIGN; APOPTOSIS; POTENT; SERIES; BENZIMIDAZOLE;

D O I：

10.2174/1570193X17666200131111851

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1, 3, 5-Triazine (s-Triazine) is a versatile nucleus to design and develop potent bioactive molecules for drug discovery, particularly in cancer therapy. The aim of this review is to present the most recent trends in the field of synthetic strategies made for functionalized triazine derivatives active against cell proliferation. This review article covers the synthesis of aryl methylamino, morpholino, triamino substituted triazines, antimitotic agents coupled triazines and many more. Many 1,3,5-triazine derivatives, both hetero-fused and uncondensed, have shown remarkable antitumor activities. We have highlighted various derivatives with 1, 3, 5-triazine core targeting different kinases with an aim to help researchers for developing new 1, 3, 5-triazine derived compounds for antitumor activity.

引用

页码：904 / 921

页数：18

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