Eltrombopag for the Treatment of Thrombocytopenia of Low and Intermediate-1 IPSS Risk Myelodysplastic Syndromes: Interim Results on Efficacy, Safety and Quality of Life of an International, Multicenter Prospective, Randomized, Trial

被引:1
|
作者
Oliva, Esther Natalie [1 ]
Santini, Valeria [2 ]
Alati, Caterina [1 ]
Poloni, Antonella [3 ]
Molteni, Alfredo [4 ]
Niscola, Pasquale [5 ]
Sanpaolo, Grazia [6 ]
Salvi, Flavia [7 ]
Palumbo, Giuseppe A. [8 ]
Balleari, Enrico [9 ]
Impera, Stefana [10 ]
Cortelezzi, Agostino [11 ]
Liberati, Anna Marina [12 ]
Avanzini, Paolo [13 ]
Di Bartolomeo, Paolo [14 ]
Rose, Christian [15 ]
Beyne-Rauzy, Odile [16 ]
Buccisano, Francesco [17 ]
Bocchia, Monica [18 ]
Morabito, Fortunato [19 ]
Stamatoullas, Aspasia [20 ]
Ronco, Francesca [1 ]
Zini, Gina [21 ]
D'Errigo, Maria Grazia [22 ]
Ranieri, Natale [1 ]
Cufari, Patrizia [1 ]
Santacaterina, Irene [1 ]
Fenaux, Pierre [23 ]
Latagliata, Roberto [24 ]
机构
[1] Azienda Osped Bianchi Melacrino Morelli, Hematol, Reggio Di Calabria, Italy
[2] Univ Florence, AOU Careggi, Florence, Italy
[3] Osped Riuniti Ancona, Haematol Clin, Ancona, Italy
[4] Osped Niguarda Ca Granda, Milan, Italy
[5] S Eugenio Hosp, Dept Hematol, Rome, Italy
[6] Ist Casa Sollievo Sofferenza, Hematol, San Giovanni Rotondo, Italy
[7] SS Antonio & Biagio Hosp, Hematol, Alessandria, Italy
[8] Univ Catania, Div Hematol, Osped Ferrarotto, Catania, Italy
[9] Genova Hosp, Genoa, Italy
[10] ARNAS Garibaldi Nesima, Sect Hematol, Catania, Italy
[11] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Oncohematol Unit, Milan, Italy
[12] Azienda Osped S Maria, SC Oncoematol, Terni, Italy
[13] Santa Maria Nuova Hosp, Hematol, Reggio Emilia, Italy
[14] Osped Civile Santo Spirito, Dipartimento Ematol, Pescara, Italy
[15] Hop St Vincent, Dept Hematol, Lille, France
[16] CHU Purpan, Serv Med Interne, Toulouse, France
[17] Univ Roma Tor Vergata, Hematol, Rome, Italy
[18] Univ Siena, Dept Hematol & Transplants, I-53100 Siena, Italy
[19] AO Annunziata Cosenza, Sect Hematol, Cosenza, Italy
[20] Ctr Henri Becquerel, Clin Hematol, F-76038 Rouen, France
[21] Univ Cattolica Sacro Cuore, Hematol, Ctr Ric ReCAMH, I-00168 Rome, Italy
[22] Azienda Osped Bianchi Melacrino Morelli, Genet Lab, Reggio Di Calabria, Italy
[23] Univ Paris 07, Hop St Louis, Serv Hematol Seniors, Paris, France
[24] Univ Roma La Sapienza, Div Hematol, Dept Cellular Biotechnol & Hematol, I-00185 Rome, Italy
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:3
相关论文
共 50 条
  • [41] LUSPATERCEPT INCREASES HEMOGLOBIN AND REDUCES TRANSFUSION BURDEN IN PATIENTS WITH LOW OR INTERMEDIATE-1 RISK MYELODYSPLASTIC SYNDROMES (MDS): PRELIMINARY RESULTS FROM A PHASE 2 STUDY
    Platzbecker, U.
    Germing, U.
    Giagounidis, A.
    Goetze, K.
    Kiewe, P.
    Mayer, K.
    Ottmann, O.
    Radsak, M.
    Wolff, T.
    Haase, D.
    Hankin, M.
    Wilson, D.
    Zhang, X.
    Laadem, A.
    Sherman, M.
    Attie, K.
    [J]. LEUKEMIA RESEARCH, 2015, 39 : S25 - S25
  • [42] Imerge: A Study to Evaluate Imetelstat (GRN163L) in Transfusion-Dependent Subjects with IPSS Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS) That Is Relapsed/Refractory to Erythropoiesis-Stimulating Agent (ESA) Treatment
    Platzbecker, Uwe
    Steensma, David P.
    Van Eygen, Koen
    Raza, Azra
    Santini, Valeria
    Germing, Ulrich
    Font, Patricia
    Diez-Campelo, Maria
    Thepot, Sylvain
    Vellenga, Edo
    Patnaik, Mrinal M.
    Jang, Jun Ho
    Sherman, Laurie
    Dougherty, Souria
    Feller, Faye
    Sun, Libo
    Wan, Ying
    Huang, Fei
    Rizo, Aleksandra
    Fenaux, Pierre
    [J]. BLOOD, 2019, 134
  • [43] Results of a Randomized, Double-Blind Study of Romiplostim Versus Placebo in Patients With Low/Intermediate-1-Risk Myelodysplastic Syndrome and Thrombocytopenia
    Giagounidis, Aristoteles
    Mufti, Ghulam J.
    Fenaux, Pierre
    Sekeres, Mikkael A.
    Szer, Jeffrey
    Platzbecker, Uwe
    Kuendgen, Andrea
    Gaidano, Gianluca
    Wiktor-Jedrzejczak, Wieslaw
    Hu, Kuolung
    Woodard, Paul
    Yang, Allen S.
    Kantarjian, Hagop M.
    [J]. CANCER, 2014, 120 (12) : 1838 - 1846
  • [44] BIOSIMILAR EPOETIN IN ELDERLY PATIENTS WITH LOW-RISK/INTERMEDIATE 1 MYELODYSPLASTIC SYNDROMES IMPROVES ANEMIA, QUALITY OF LIFE AND BRAIN FUNCTION
    Castelli, R.
    Deliliers, G. Lambertenghi
    Colombo, R.
    Gallipoli, P.
    Pantaleo, G.
    [J]. HAEMATOLOGICA, 2014, 99 : 616 - 616
  • [45] ACE-536 Increases Hemoglobin and Reduces Transfusion Burden in Patients with Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS): Preliminary Results from a Phase 2 Study
    Platzbecker, Uwe
    Germing, Ulrich
    Giagounidis, Aristoteles
    Goetze, Katharina
    Kiewe, Philipp
    Mayer, Karin
    Ottman, Oliver
    Radsak, Markus P.
    Wolff, Thomas
    Haase, Detlef
    Hankin, Monty
    Wilson, Dawn M.
    Laadem, Adberrahmane
    Sherman, Matthew L.
    Attie, Kenneth M.
    [J]. BLOOD, 2014, 124 (21)
  • [46] Health-related quality of life outcomes of lenalidomide in transfusion-dependent patients with Low- or Intermediate-1-risk myelodysplastic syndromes with a chromosome 5q deletion: Results from a randomized clinical trial
    Revicki, Dennis A.
    Brandenburg, Nancy A.
    Muus, Petra
    Yu, Ren
    Knight, Robert
    Fenaux, Pierre
    [J]. LEUKEMIA RESEARCH, 2013, 37 (03) : 259 - 265
  • [47] Allogeneic Hematopoietic Stem Cell Transplantation (allo HSCT) in Patients with IPSS Low or Intermediate-1 Myelodysplastic Syndrome (MDS): A Prospective Multicenter Phase II Study Based on Donor Availability By the GFM & SFGM-TC "MDS-ALLO-Risk"
    Sebert, Marie
    Chaffaut, Cendrine
    Thepot, Sylvain
    Orvain, Corentin
    Cluzeau, Thomas
    Loschi, Michael
    Peterlin, Pierre
    Chevallier, Patrice
    d'Aveni, Maud
    Rubio, Marie-Therese
    Rauzy, Odile Beyne
    Huynh, Anne
    Charbonnier, Amandine
    Fegueux, Nathalie
    Fossard, Gaelle
    N'guyen-Quoc, Stephanie
    Park, Sophie
    Sapena, Rosa
    Chermat, Fatiha
    Ades, Lionel
    Chevret, Sylvie
    Fenaux, Pierre
    Robin, Marie
    [J]. BLOOD, 2021, 138 : 1842 - +
  • [48] Treatment of transfusional iron overload with deferasirox in patients with low and intermediate-1 risk MDS: Results from a German multi-center trial
    Nolte, F.
    Hoechsmann, B.
    Luebbert, M.
    Platzbecker, U.
    Haase, D.
    Lueck, A.
    Gattermann, N.
    Giagounidis, A.
    May, C.
    Leismann, O.
    Junkes, A.
    Schumann, C.
    Hofmann, W. -K
    Schrezenmeier, H.
    [J]. ONKOLOGIE, 2011, 34 : 290 - 290
  • [49] Preliminary safety and efficacy of oral azacitidine (Oral-AZA) in patients (pts) with low-/Intermediate (Int)-risk myelodysplastic syndromes (MDS): Phase 2 results from the ASTREON trial
    Garcia-Manero, Guillermo
    Yee, Karen W. L.
    Hernandez, Francisca
    Della Porta, Matteo Giovanni
    Paolini, Stefania
    Ahn, Seo-Yeon
    Santini, Valeria
    Fenaux, Pierre
    Suzuki, Takahiro
    Sekeres, Mikkael A.
    He, Jun
    Li, Jerry
    Barkalifa, Ronit
    Vigil, Carlos E.
    Prebet, Thomas
    de Menezes, Daniel Lopes
    Burnett, Joseph
    Komrokji, Rami S.
    Giagounidis, Aristoteles
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [50] Randomized Phase II Study Evaluating the Efficacy and Safety of Romiplostim Treatment of Patients with Low or Intermediate Risk Myelodysplastic Syndrome (MDS) Receiving Lenalidomide
    Lyons, Roger M.
    Larson, Richard A.
    Kosmo, Michael A.
    Gandhi, Sunil
    Liu, Delong
    Chernoff, Marc
    Dreisbach, Luke
    Matei, Carmen
    Hu, Kuolong
    Franklin, Janet L.
    Berger, Dietmar
    [J]. BLOOD, 2009, 114 (22) : 703 - 704