Mortality in Relation to Changes in a Healthy Aging Index: The Health, Aging, and Body Composition Study

被引:20
|
作者
O'Connell, Matthew D. L. [1 ,2 ,3 ]
Marron, Megan M. [1 ]
Boudreau, Robert M. [1 ]
Canney, Mark [2 ]
Sanders, Jason L. [4 ]
Kenny, Rose Anne [2 ]
Kritchevsky, Stephen B. [5 ]
Harris, Tamara B. [6 ]
Newman, Anne B. [1 ]
机构
[1] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Ctr Aging & Populat Hlth, Pittsburgh, PA 15260 USA
[2] Trinity Coll Dublin, Dept Med Gerontol, Irish Longitudinal Study Ageing, Dublin, Ireland
[3] Univ Warwick, Warwick Med Sch, Div Hlth Sci, Unit Acad Primary Care, Coventry, W Midlands, England
[4] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA
[5] Wake Forest Sch Med, Dept Internal Med, Sticht Ctr Hlth Aging & Alzheimers Prevent, Winston Salem, NC USA
[6] NIA, Lab Epidemiol & Populat Sci, Bethesda, MD 20892 USA
关键词
Successful aging; Epidemiology; Mortality; Physiology; OLDER-ADULTS; PHYSIOLOGICAL INDEX; ASSOCIATION; TRAJECTORIES; COMORBIDITY; PHENOTYPE; DISEASE; SCORE; AGE;
D O I
10.1093/gerona/gly114
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: Baseline scores on a Healthy Aging Index (HAI), including five key physiologic domains, strongly predict health outcomes. This study aimed to characterize 9-year changes in a HAI and explore their relationship to subsequent mortality. Methods: Data are from the Health, Aging, and Body Composition study of well-functioning adults aged 70-79 years. A HAI, which ranges from 0 to 10, was constructed at years 1 and 10 of the study including systolic blood pressure, forced expiratory volume, digit symbol substitution test, cystatin C, and fasting glucose. The relationships between the HAI at years 1 and 10 and the change between years and subsequent mortality until year 17 were estimated from Cox proportional hazards models. Results: Two thousand two hundred sixty-four participants had complete data on a HAI at year 1, of these 1,122 had complete data at year 10. HAI scores tended to increase (i.e. get worse) over 9-year follow-up, from (mean [SD]) 4.3 (2.1) to 5.7 (2.1); mean within-person change 1.5 (1.6). After multivariable adjustment, HAI score was related to mortality from year 1 (hazard ratio [95% confidence interval] = 1.17 [1.13-1.21] per unit) and year 10 (1.20 [1.14-1.27] per unit). The change between years was also related to mortality (1.08 [1.02-1.15] per unit change). Conclusions: HAI scores tended to increase with advancing age and stratified mortality rates among participants remaining at year 10. The HAI may prove useful to understand changes in health with aging.
引用
收藏
页码:726 / 732
页数:7
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