Overexpression of EZH2 associates with a poor prognosis in chronic lymphocytic leukemia

被引：29

作者：

Rabello, Doralina do Amaral ^{[1
]}

Lucena-Araujo, Antonio Roberto ^{[2
]}

Rocha Alves-Silva, Juliana Carvalho ^{[1
]}

Aboud Souza da Eira, Vinicius Burnett ^{[1
]}

Cals de Vasconcellos, Maria Catarina ^{[3
]}

de Oliveira, Fabio Morato ^{[2
]}

Rego, Eduardo Magalhaes ^{[2
]}

Saldanha-Araujo, Felipe ^{[1
]}

Silva, Fabio Pittella ^{[1
]}

机构：

[1] Univ Brasilia, Lab Mol Pathol Canc, BR-70910900 Brasilia, DF, Brazil

[2] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Internal Med, BR-14048900 Ribeirao Preto, SP, Brazil

[3] Hosp Base Dist Fed, Setor Hosp Sul, Area Especial, BR-70330150 Brasilia, DF, Brazil

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2015年 / 54卷 / 01期

关键词：

Chronic lymphocytic leukemia; EZH2; Histone methyltransferase; Gene expression; Cytogenetic; ZAP-70; EXPRESSION; POLYCOMB; MECHANISMS; DIAGNOSIS; CELLS;

D O I：

10.1016/j.bcmd.2014.07.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

EZH2, a histone methyltransferase, is overexpressed in several human tumors, but whether it exerts any impact in chronic lymphocytic leukemia (CLL) remains unknown. We used real time PCR to investigate the expression profile of EZH1 and EZH2 in 59 CLL patients, 10 samples of purified B-cells from healthy donors and 12 normal adult tissues. EZH2 was overexpressed in CLL patients and correlates with high white blood cell count, ZAP-70 expression and chromosomal abnormalities. EHZ1 expression does not correlate with CLL progression. EZH2 overexpression is related to a poor prognosis of CLL and could be a useful tool to assess its aggressiveness. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：97 / 102

页数：6

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