Core-shell structured pullulan based nanocomposites as erlotinib delivery shuttles

被引：16
|
作者：
Bera, Hriday [1 ]
Ang, Sher Reen [1 ]
Chiong, Siew Wen [1 ]
Chan, Chong Hong [1 ]
Abbasi, Yasir Faraz [1 ]
Law, Lee Ping [1 ]
Chatterjee, Bappadity [2 ]
Venugopal, Vijayan [1 ]
机构：
[1] AIMST Univ, Fac Pharm, Bedong 08100, Kedah, Malaysia
[2] Int Islamic Univ Malaysia, Kulliyyah Pharm, Kuala Lumpur, Malaysia
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2020年 / 69卷 / 13期
关键词：
Carboxymethyl pullulan; organic-inorganic nanocomposites; core-shell structure; dissolution enhancement; drug delivery; IN-VITRO EVALUATION; DRUG-DELIVERY; MESOPOROUS SILICA; NANOPARTICLES; ALGINATE; BEADS; COMPOSITE; MATRICES; ANTIBACTERIAL; COMPLEXES;
D O I：
10.1080/00914037.2019.1626389
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Anionic biopolymer (sodium alginate/low-methoxyl pectin/gellan gum) coated carboxymethyl pullulan-ZnO nanocomposites encapsulating erlotinib were developed for lung cancer therapy. The thermal, X-ray and infrared analyses suggested an environment in the nanocomposites compatible with the drug, except certain degree of attenuation in drug's crystallinity. SEM studies revealed the irregular morphology of the nanocomposites. The uncoated and coated formulations demonstrated excellent drug encapsulation efficiency and pH dependent dissolution behavior, which was significantly improved as compared to pristine drug. The drug release profiles of the core-shell nanocomposites (F-4) in acidic and neutral media were best fitted in Korsemeyer-Peppas and zero-order kinetic model, respectively. [GRAPHICS] .
引用
收藏
页码：848 / 859
页数：12
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