Core-shell structured pullulan based nanocomposites as erlotinib delivery shuttles

被引：16

作者：

Bera, Hriday ^{[1
]}

Ang, Sher Reen ^{[1
]}

Chiong, Siew Wen ^{[1
]}

Chan, Chong Hong ^{[1
]}

Abbasi, Yasir Faraz ^{[1
]}

Law, Lee Ping ^{[1
]}

Chatterjee, Bappadity ^{[2
]}

Venugopal, Vijayan ^{[1
]}

机构：

[1] AIMST Univ, Fac Pharm, Bedong 08100, Kedah, Malaysia

[2] Int Islamic Univ Malaysia, Kulliyyah Pharm, Kuala Lumpur, Malaysia

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2020年 / 69卷 / 13期

关键词：

Carboxymethyl pullulan; organic-inorganic nanocomposites; core-shell structure; dissolution enhancement; drug delivery; IN-VITRO EVALUATION; DRUG-DELIVERY; MESOPOROUS SILICA; NANOPARTICLES; ALGINATE; BEADS; COMPOSITE; MATRICES; ANTIBACTERIAL; COMPLEXES;

D O I：

10.1080/00914037.2019.1626389

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Anionic biopolymer (sodium alginate/low-methoxyl pectin/gellan gum) coated carboxymethyl pullulan-ZnO nanocomposites encapsulating erlotinib were developed for lung cancer therapy. The thermal, X-ray and infrared analyses suggested an environment in the nanocomposites compatible with the drug, except certain degree of attenuation in drug's crystallinity. SEM studies revealed the irregular morphology of the nanocomposites. The uncoated and coated formulations demonstrated excellent drug encapsulation efficiency and pH dependent dissolution behavior, which was significantly improved as compared to pristine drug. The drug release profiles of the core-shell nanocomposites (F-4) in acidic and neutral media were best fitted in Korsemeyer-Peppas and zero-order kinetic model, respectively. [GRAPHICS] .

引用

页码：848 / 859

页数：12

共 50 条

[1] Core-Shell Structured Nanocomposites with Electromagnetic Properties
Wang, Xichang
Li, Xin
[J]. CURRENT TRENDS IN THE DEVELOPMENT OF INDUSTRY, PTS 1 AND 2, 2013, 785-786 : 607 - 612
[2] Design of Core-Shell Stearyl Pullulan Nanostructures for Drug Delivery
Laha, Bibek
Maiti, Sabyasachi
[J]. MATERIALS TODAY-PROCEEDINGS, 2019, 11 : 620 - 627
[3] Core-Shell Structured Nanocomposites for Photocatalytic Selective Organic Transformations
Liu, Siqi
Zhang, Nan
Xu, Yi-Jun
[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 2014, 31 (05) : 540 - 556
[4] Size effect of nanomagnetite on magnetoresistance of core-shell structured polyaniline nanocomposites
Jiang Guo
Shaohua Xi
Yukun Sun
Wenhao Dong
Yazeed M. Asiri
Nawal D. Alqarni
Mohamed H. Helal
Fujian Zhou
Jianfeng Zhu
[J]. Advanced Composites and Hybrid Materials, 2024, 7
[5] Core-shell structured cadmium sulfide nanocomposites for solar energy utilization
Zhang, Jin
Yuan, Xingzhong
Si, Mengying
Jiang, Longbo
Yu, Hanbo
[J]. ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2020, 282
[6] Size effect of nanomagnetite on magnetoresistance of core-shell structured polyaniline nanocomposites
Guo, Jiang
Xi, Shaohua
Sun, Yukun
Dong, Wenhao
Asiri, Yazeed M.
Alqarni, Nawal D.
Helal, Mohamed H.
Zhou, Fujian
Zhu, Jianfeng
[J]. ADVANCED COMPOSITES AND HYBRID MATERIALS, 2024, 7 (02)
[7] Core-Shell Structured Theranostics
Guan, Qingwen
Wang, Min
[J]. NANO LIFE, 2021, 11 (04)
[8] Core-shell structured nanoprecipitates in zirconium based alloy
Liu, Chengze
Li, Geping
Yuan, Fusen
Han, Fuzhou
Ali, Muhammad
Zhang, Yingdong
Guo, Wenbin
Gu, Hengfei
[J]. SCRIPTA MATERIALIA, 2020, 185 : 170 - 174
[9] Cobalt and silica based core-shell structured nanospheres
Salgueirino-Maceira, Veronica
Correa-Duarte, Miguel A.
[J]. JOURNAL OF MATERIALS CHEMISTRY, 2006, 16 (36) : 3593 - 3597
[10] pH-Responsive Magnetic Core-Shell Nanocomposites for Drug Delivery
Yang, Chunyu
Guo, Wei
Cui, Liru
An, Na
Zhang, Ting
Lin, Huiming
Qu, Fengyu
[J]. LANGMUIR, 2014, 30 (32) : 9819 - 9827

← 1 2 3 4 5 →