Oncolytic Viral Therapy of Malignant Glioma

被引：62

作者：

Parker, Jacqueline Nuss ^{[2
]}

Bauer, David F. ^{[1
]}

Cody, James J. ^{[2
]}

Marker, James M. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Surg, Div Neurosurg, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Dept Pediat, Div Infect Dis, Birmingham, AL 35294 USA

来源：

NEUROTHERAPEUTICS | 2009年 / 6卷 / 03期

关键词：

Oncolytic viral therapy; malignant glioma; G207; HSV; 1716; ONYX-015; adenovirus; Reolysin; vaccinia; Newcastle disease virus; measles virus; HERPES-SIMPLEX-VIRUS; NEWCASTLE-DISEASE VIRUS; RECOMBINANT VACCINIA VIRUS; MUTANT EXPRESSING ICP34.5; POTENT ANTITUMOR-ACTIVITY; HIGH-GRADE GLIOMA; PHASE-I TRIAL; RIBONUCLEOTIDE REDUCTASE; GENE-THERAPY; SAFETY EVALUATION;

D O I：

10.1016/j.nurt.2009.04.011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Novel approaches to treatment of malignant glioma, the most frequently occurring primary brain tumor, have included the use of a wide range of oncolytic viral vectors. These vectors, either naturally tumor-selective, or engineered as such, have shown promise in the handful of phase I and phase II clinical trials conducted in recent years. The strategies developed for each of the different viruses currently being studied and the history of their development are summarized here. In addition, the results of clinical trials in patients and their implication for future trials are also discussed.

引用

页码：558 / 569

页数：12

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