SELECTIVE NATURAL κ OPIOID AND CANNABINOID RECEPTOR AGONISTS WITH A POTENTIAL ROLE IN THE TREATMENT OF GASTROINTESTINAL DYSFUNCTION

被引：18
|
作者：
Fichna, Jakub [1 ]
Schicho, Rudolf [2 ]
Janecko, Anna [1 ]
Zjawiony, Jordan K. [3 ]
Storr, Martin [2 ]
机构：
[1] Med Univ Lodz, Fac Med, Dept Biomol Chem, Lodz, Poland
[2] Univ Calgary, Dept Med, Div Gastroenterol, Calgary, AB T2N 4N1, Canada
[3] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA
来源：
DRUG NEWS & PERSPECTIVES | 2009年 / 22卷 / 07期
关键词：
SALVINORIN-A ANALOGS; IRRITABLE-BOWEL-SYNDROME; PLANT-DERIVED HALLUCINOGEN; HERB SALVIA-DIVINORUM; NEOCLERODANE DITERPENES; IN-VITRO; ENDOCANNABINOID SYSTEM; INDUCED HYPERMOTILITY; COLONIC INFLAMMATION; INDUCED INHIBITION;
D O I：
10.1358/dnp.2009.22.7.1400219
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Salvinorin A is the major active ingredient of Salvia divinorum, a plant used by the Mazatec Indians of Mexico for spiritual and medical purposes. Different preparations from S. divinorum are also used in traditional heating practices to treat gastrointestinal disorders, including diarrhea. The recent extensive research on salvinorin A and other neoclerodane diterpenoids derived from S. divinorum resulted in a large number of reports describing their isolation, synthesis and structure-activity relationship. This review summarizes the present knowledge on salvinorin A and its analogues, with a focus on the effects on gastrointestinal tissues. We furthermore discuss structural changes in salvinorin A that may facilitate future use of its derivatives in human disease.
引用
收藏
页码：383 / 392
页数：10
相关论文
共 50 条
  • [21] MODULATION OF HYPOXIC TOLERANCE BY SELECTIVE OPIOID RECEPTOR AGONISTS
    MAYFIELD, KP
    DALECY, LG
    FASEB JOURNAL, 1993, 7 (03): : A404 - A404
  • [22] The role of opioid receptor agonists in ischemic preconditioning
    Dragasis, Stylianos
    Bassiakou, Eleni
    Iacovidou, Nicoletta
    Papadimitriou, Louiza
    Steen, Petter Andreas
    Gulati, Anil
    Xanthos, Theodoros
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 720 (1-3) : 401 - 408
  • [23] Selective nicotinic acetylcholine receptor agonists: Potential therapies for neuropsychiatric disorders with cognitive dysfunction
    Cincotta, Stephanie L.
    Yorek, Matthew S.
    Moschak, Travis M.
    Lewis, Samantha R.
    Rodefer, Joshua S.
    CURRENT OPINION IN INVESTIGATIONAL DRUGS, 2008, 9 (01) : 47 - 56
  • [24] Emerging role of cannabinoids and synthetic cannabinoid receptor 1/cannabinoid receptor 2 receptor agonists in cancer treatment and chemotherapy-associated cancer management
    Shah, Siddharth A.
    Gupta, Anand Shyamlal
    Kumar, Piyush
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2021, 17 (01) : 1 - 9
  • [25] The μ-opioid receptor agonist morphine, but not agonists at δ- or κ-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors
    Pacheco, D. da Fonseca
    Klein, A.
    Perez, A. de Castro
    Pacheco, C. M. da Fonseca
    de Francischi, J. N.
    Duarte, I. D. G.
    BRITISH JOURNAL OF PHARMACOLOGY, 2008, 154 (05) : 1143 - 1149
  • [26] Development of Chromenopyrazole-Based Selective Cannabinoid 2 Receptor Agonists
    Singh, Sameek
    Liddle, Ian
    Macdonald, Christa
    Tyndall, Joel D. A.
    Glass, Michelle
    Vernall, Andrea J.
    AUSTRALIAN JOURNAL OF CHEMISTRY, 2021, 74 (06) : 433 - 442
  • [27] Synthetic cannabinoid receptor agonists are monoamine oxidase-A selective inhibitors
    Hindson, Sarah A.
    Andrews, Rachael C.
    Danson, Michael J.
    van Der Kamp, Marc W.
    Manley, Amy E.
    Sutcliffe, Oliver B.
    Haines, Tom S. F.
    Freeman, Tom P.
    Scott, Jennifer
    Husbands, Stephen M.
    Blagbrough, Ian S.
    Anderson, J. L. Ross
    Carbery, David R.
    Pudney, Christopher R.
    FEBS JOURNAL, 2023, 290 (12) : 3243 - 3257
  • [28] Behavioral effects of δ-opioid receptor agonists:: Potential antidepressants?
    Broom, DC
    Jutkiewicz, EM
    Rice, KC
    Traynor, JR
    Woods, JH
    JAPANESE JOURNAL OF PHARMACOLOGY, 2002, 90 (01): : 1 - 6
  • [29] Abuse Potential of Biased Mu Opioid Receptor Agonists
    Negus, S. Stevens
    Freeman, Kevin B.
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2018, 39 (11) : 916 - 919
  • [30] Peripherally Selective Cannabinoid 1 Receptor (CB1R) Agonists for the Treatment of Neuropathic Pain
    Seltzman, Herbert H.
    Shiner, Craig
    Hirt, Erin E.
    Gilliam, Anne F.
    Thomas, Brian F.
    Maitra, Rangan
    Snyder, Rod
    Black, Sherry L.
    Patel, Purvi R.
    Mulpuri, Yatendra
    Spigelman, Igor
    JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (16) : 7525 - 7543
12345