Oxaliplatin, 5-fluorouracil, and folinic acid (Folfox) in patients with metastatic renal cell carcinoma - Results of a pilot study

被引：11
|
作者：
Chaouche, M
Pasturaud, AL
Kamioner, D
Grandjean, M
Franiatte, J
Tourani, JM
机构：
[1] Hop Jean Bernard, Dept Oncol, F-86021 Poitiers, France
[2] Pasteur Hosp, Oncol Unit, Brest, France
[3] Laennec Hosp, Oncol Unit, Paris, France
[4] Trappes Hosp, Oncol Unit, Trappes, France
来源：
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 2000年 / 23卷 / 03期
关键词：
5-fluorouracil; immunotherapy; oxaliplatin; renal cell carcinoma;
D O I：
10.1097/00000421-200006000-00016
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report the results of a chemotherapy regimen combining oxaliplatin, 5-fluorouracil, and folinic acid in patients with metastatic renal cell carcinoma. The objective of this pilot study was to define the potential efficacy of this second-line combination in patients previously treated with interleukin-2 alone or in combination with interferon alpha. Fourteen patients with metastatic renal cell carcinoma in failure after immunotherapy were included in this trial. During treatment, patients received six chemotherapy courses (Folfox regimen) administered every 2 weeks. Each cycle combined oxaliplatin day (D) D1 and folinic acid plus 5-fluorouracil D1 and D2. At completion of treatment, no objective response was observed and two patients presented stable disease. This chemotherapy schedule in patients with metastatic renal cell carcinoma previously treated with immunotherapy does not seem to be effective.
引用
收藏
页码：288 / 289
页数：2
相关论文
共 50 条
  • [41] A randomised phase II study of oxaliplatin alone versus oxaliplatin combined with 5-fluorouracil and folinic acid (Mayo Clinic regimen) in previously untreated metastatic colorectal cancer patients
    Comba, AZ
    Blajman, C
    Richardet, E
    Bella, S
    Vilanova, M
    Cóppola, F
    Van Kooten, M
    Rodger, J
    Giglio, R
    Balbiani, L
    Perazzo, F
    Montiel, M
    Chacón, M
    Pujol, F
    Mickiewicz, E
    Cazap, E
    Recondo, G
    Lastiri, F
    Simon, J
    Wasserman, E
    Schmilovich, A
    EUROPEAN JOURNAL OF CANCER, 2001, 37 (08) : 1006 - 1013
  • [42] Treatment with 5-fluorouracil/folinic acid, oxaliplatin, and irinotecan enables surgical resection of metastases in patients with initially unresectable metastatic colorectal cancer
    Masi, G
    Cupini, S
    Marcucci, L
    Cerri, E
    Loupakis, F
    Allegrini, G
    Brunetti, IM
    Pfanner, E
    Viti, M
    Goletti, O
    Filipponi, F
    Falcone, A
    ANNALS OF SURGICAL ONCOLOGY, 2006, 13 (01) : 58 - 65
  • [43] Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/folinic acid plus oxaliplatin (FOLFOX-4) as second-line therapy in metastatic colorectal cancer: a randomized phase III noninferiority study
    Rothenberg, M. L.
    Cox, J. V.
    Butts, C.
    Navarro, M.
    Bang, Y. -J.
    Goel, R.
    Gollins, S.
    Siu, L. L.
    Laguerre, S.
    Cunningham, D.
    ANNALS OF ONCOLOGY, 2008, 19 (10) : 1720 - 1726
  • [44] Effect of stomatitis on patients treated with adjuvant 5-fluorouracil and folinic acid for colorectal carcinoma
    Assersohn, L
    Webb, A
    Cunningham, D
    Ross, P
    Smith, A
    Norman, A
    Hey, L
    GI CANCER, 1999, 3 (01): : 61 - 66
  • [45] Triplet combination of gemcitabine, paclitaxel, and carboplatin followed by maintenance 5-fluorouracil and folinic acid in patients with metastatic nasopharyngeal carcinoma
    Leong, Swan Swan
    Wee, Joseph
    Rajan, Sandeep
    Toh, Chee Keong
    Lim, Wan Teck
    Hee, Siew Wan
    Tay, Miah Hiang
    Poon, Donald
    Tan, Eng Huat
    CANCER, 2008, 113 (06) : 1332 - 1337
  • [46] Bimonthly Chemotherapy with Oxaliplatin, Irinotecan, Infusional 5-Fluorouracil/Folinic Acid in Patients with Metastatic Colorectal Cancer Pretreated with Irinotecan- or Oxaliplatin-Based Chemotherapy
    Nobili, S.
    Checcacci, D.
    Filippelli, F.
    Del Buono, S.
    Mazzocchi, V.
    Mazzei, T.
    Mini, E.
    JOURNAL OF CHEMOTHERAPY, 2008, 20 (05) : 622 - 631
  • [47] CETUXIMAB COMBINED WITH INFUSIONAL 5-FLUOROURACIL/FOLINIC ACID AND OXALIPLATIN IN METASTATIC COLORECTAL CANCER: POOLED ANALYSIS OF COIN AND OPUS STUDY DATA
    Taieb, Julien
    Maughan, Tim
    Bokemeyer, Carsten
    Van Cutsem, Eric
    Brodowicz, Thomas
    Folprecht, Gunnar
    Esser, Regina
    Schlichting, Michael
    Tabernero, Josep
    ANNALS OF ONCOLOGY, 2012, 23 : 11 - 11
  • [48] Phase I-II study of gamma interferon and 5-fluorouracil for patients with metastatic renal cell carcinoma
    DeLima, M
    Amato, RJ
    Jackson, A
    Tu, SM
    Banks, M
    Finn, L
    Ellerhorst, J
    CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 1997, 12 (06) : 365 - 370
  • [49] PROGNOSTIC FACTORS IN PATIENTS WITH METASTATIC COLORECTAL-CANCER RECEIVING 5-FLUOROURACIL AND FOLINIC ACID
    STEINBERG, J
    ERLICHMAN, C
    GADALLA, T
    FINE, S
    WONG, A
    EUROPEAN JOURNAL OF CANCER, 1992, 28A (11) : 1817 - 1820
  • [50] 5-fluorouracil leucovorin and oxaliplatin (FOLFOX) in the treatment of metastatic colon cancer with severe liver dysfunction
    Fakih, MG
    ONCOLOGY, 2004, 67 (3-4) : 222 - 224
12345