Combined inhibition of complement and CD14 significantly improved survival and reversed hemodynamic changes in polymicrobial porcine sepsis

被引:0
|
作者
Skjeflo, Espen Waage [1 ,2 ]
Barratt-Due, Andreas [3 ,4 ,5 ]
Dybwik, Knut [1 ,6 ,7 ]
Urving, Sven Hakon [7 ]
Nunn, Miles [8 ]
Lau, Corinna [2 ]
Nielsen, Erik Waage [1 ,6 ,7 ]
Mollnes, Tom Eirik [1 ,2 ,3 ,4 ]
机构
[1] Univ Tromso, Fac Hlth Sci, N-9001 Tromso, Norway
[2] Nordland Hosp, Res Lab, Bodo, Norway
[3] Oslo Univ Hosp, Dept Immunol, Oslo, Norway
[4] Univ Oslo, N-0316 Oslo, Norway
[5] Oslo Univ Hosp, Div Emergencies & Crit Care, Oslo, Norway
[6] Univ Nordland, Bodo, Norway
[7] Nordland Hosp, Dept Anesthesiol, Bodo, Norway
[8] Volut Immuno Pharmaceut Ltd SA, Zurich, Switzerland
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
171
引用
收藏
页码:276 / 276
页数:1
相关论文
共 30 条
  • [21] Combined Inhibition of Complement and CD14 Efficiently Attenuated the Inflammatory Response Induced by Staphylococcus aureus in a Human Whole Blood Model
    Skjeflo, Espen W.
    Christiansen, Dorte
    Espevik, Terje
    Nielsen, Erik W.
    Mollnes, Tom E.
    JOURNAL OF IMMUNOLOGY, 2014, 192 (06): : 2857 - 2864
  • [22] Combined inhibition of complement and CD14 efficiently attenuated the inflammatory response induced by Staphylococcus aureus in a human whole blood model
    Skjeflo, Espen
    Christiansen, Dorte
    Lambris, John D.
    Espevik, Terje
    Nielsen, Erik Waage
    Mollnes, Tom Eirik
    IMMUNOBIOLOGY, 2012, 217 (11) : 1152 - 1153
  • [23] CD14 inhibition improves survival and attenuates thrombo-inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis
    Keshari, Ravi S.
    Silasi, Robert
    Popescu, Narcis, I
    Regmi, Girija
    Chaaban, Hala
    Lambris, John D.
    Lupu, Cristina
    Mollnes, Tom E.
    Lupu, Florea
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2021, 19 (02) : 429 - 443
  • [24] Combined complement C3 and CD14 inhibition reduce Escherichia coli-induced thromboinflammation in the presence and absence of antibiotics
    Joakimsen, Ingrid Sofie
    Karlsen, Board Ove
    Emblem, Ase Eeg
    Pettersen, Kristin
    Gronl, Renathe Henriksen
    Mollnes, Tom Erik
    Brekkel, Ole Lars
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2024, 54 : 65 - 65
  • [25] Ornithodoros moubata complement inhibitor (OmCI) is an equally effective C5 inhibitor in pig and human, and combined with CD14 inhibition, efficiently attenuate Escherichia coli-induced sepsis in pigs
    Barratt-Due, A.
    Thorgersen, E. B.
    Lindstad, J. K.
    Pharo, A.
    Lambris, J. D.
    Nunn, M. A.
    Mollnes, T. E.
    MOLECULAR IMMUNOLOGY, 2011, 48 (14) : 1699 - 1699
  • [26] The CD14 rs2569190 TT Genotype Is Associated with an Improved 30-Day Survival in Patients with Sepsis: A Prospective Observational Cohort Study
    Mansur, Ashham
    Liese, Benjamin
    Steinau, Maximilian
    Ghadimi, Michael
    Bergmann, Ingo
    Tzvetkov, Mladen
    Popov, Aron Frederik
    Beissbarth, Tim
    Bauer, Martin
    Hinz, Jose
    PLOS ONE, 2015, 10 (05):
  • [27] DUAL INHIBITION OF COMPLEMENT AND CD14 ATTENUATED THE RELEASE OF PRO-INFLAMMATORY CYTOKINES IN HUMAN WHOLE BLOOD EX VIVO WHEN IN CONTACT WITH DECELLULARIZED PORCINE CORNEA
    Islam, Rakibul
    Islam, Mohammad Mirazul
    Nilsson, Per H.
    Mohlin, Camilla
    Hagen, Kjersti Thorvaldsen
    Gonzalez-Andrades, Miguel
    Mollnes, Tom Eirik
    MOLECULAR IMMUNOLOGY, 2019, 114 : 483 - 483
  • [28] Combined inhibition of complement and CD14 abolish E-coli-induced cytokine-, chemokine- and growth factor-synthesis in human whole blood
    Brekke, Ole-Lars
    Christiansen, Dorte
    Fure, Hilde
    Pharo, Anne
    Fung, Michael
    Riesenfeld, Johan
    Mollnes, Tom Eirik
    MOLECULAR IMMUNOLOGY, 2008, 45 (14) : 3804 - 3813
  • [29] Combined C5aR1 and CD14 inhibition significantly reduced cytokine release induced by both viable and heat inactivated bacteria in human whole blood
    Christiansen, Dorte
    Skjeflo, Espen Waage
    Landsem, Anne
    Fure, Hilde
    Ludviksen, Judith K.
    Stenvik, Jurgen
    Woodruff, Trent
    Espevik, Terje
    Mollnes, Tom Eirik
    MOLECULAR IMMUNOLOGY, 2017, 89 : 169 - 170
  • [30] Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4-MD2 Complex
    Gustavsen, Alice
    Nymo, Stig
    Landsem, Anne
    Christiansen, Dorte
    Ryan, Liv
    Husebye, Harald
    Lau, Corinna
    Pischke, Soren E.
    Lambris, John D.
    Espevik, Terje
    Mollnes, Tom E.
    JOURNAL OF INFECTIOUS DISEASES, 2016, 214 (01): : 140 - 150