Synthesis of biologically important 4-Phenyl-C-glycosyl-1,2,3-triazole derivatives by Cu(I)-catalyzed azide-alkyne cycloaddition

被引：0

作者：

Ponnapalli, Kalyana K. ^{[1
]}

Kawade, Sachin K. ^{[1
]}

Adak, Avijit K. ^{[1
]}

Wu, Hsin-Ru ^{[2
]}

Lin, Chun-Cheng ^{[1
,3
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu, Taiwan

[2] Natl Tsing Hua Univ, Instrumentat Ctr, Hsinchu, Taiwan

[3] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 80708, Taiwan

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2021年 / 68卷 / 06期

关键词：

1,2,3-triazoles; C-glycosides; click chemistry; CuAAC; disaccharide; CLICK CHEMISTRY; ACID;

D O I：

10.1002/jccs.202000452

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of 4-phenyl-C-glycosyl-1,2,3-triazoles were synthesized using Cu(I)- catalyzed azide-alkyne cycloaddition. The key step in the synthesis involved the coupling of unprotected glycosyl azides with substituted C-glycosylated phenyl acetylenes. Using o-phenylenediamine as a ligand, we could significantly reduce the reaction time, improve the product yield, and simplify the purification process. Broad substrate scope in terms of sugars was achieved.

引用

页码：1156 / 1161

页数：6

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