CpG oligonucleotides improve the protective immune response induced by the anthrax vaccination of rhesus macaques

被引：72

作者：

Klinman, DA

Xie, H

Little, SF

Currie, D

Ivins, BE

机构：

[1] US FDA, Ctr Biol Evaluat & Res, Sect Retroviral Immunol, Bethesda, MD 20892 USA

[2] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD USA

来源：

VACCINE | 2004年 / 22卷 / 21-22期

关键词：

CpG oligonucleotide; anthrax; vaccine adjuvant;

D O I：

10.1016/j.vaccine.2003.12.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants, improving the immune response elicited by co-administered vaccines. Combining CpG ODN with anthrax vaccine adsorbed (AVA, the licensed human vaccine) increased the speed, magnitude and avidity of the resultant anti-anthrax response. The protective activity of these Abs was established by passive transfer to anthrax-challenged mice. The ability of CpG ODN to accelerate and magnify the immune response to AVA suggests this strategy may contribute to the development of prophylactic and therapeutic vaccines against biothreat pathogens. Published by Elsevier Ltd.

引用

页码：2881 / 2886

页数：6

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