Self-assembly of fibers and fibrils

被引：54
|
作者：
Binder, Wolfgang H.
Smrzka, Oskar W.
机构：
[1] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria
[2] St Anna Kinderkrebsforsch, Childrens Canc Res Inst, A-1090 Vienna, Austria
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 44期
关键词：
Alzheimer's disease; fibrous proteins; gelators; peptides; self-assembly;
D O I：
10.1002/anie.200602001
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Too much fiber? Protein fibers play an important role in cellular processes, but are also involved in protein-folding diseases, such as Alzheimer's disease. Modern screening and validation models allow the investigation of the aggregation and deaggregation kinetics of protein fibers (see scheme). These studies can serve as a starting point for the development of new therapeutic strategies. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：7324 / 7328
页数：5
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