Immune system regulation of transgene expression in the brain 1: Systemically activated immune responses silence adenoviral vector-encoded transgene expression in the brain through both non-cytolytic, and cytotoxic mechanisms

被引:0
|
作者
Barcia, C
Thomas, C
Zirger, J
Xiong, WD
Boyer, O
Klatzmann, D
Castro, MG
Lowenstein, PR
机构
[1] Cedars Sinai Med Ctr, Gene Therapeut Res Inst, Los Angeles, CA 90048 USA
[2] Hop La Pitie Salpetriere, Dept Virol, Paris, France
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D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
459
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页码:S174 / S175
页数:2
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    Thomas, C
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    [J]. FASEB JOURNAL, 2005, 19 (04): : A4 - A4
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    Zirger, JM
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    Abordo-Adesida, E
    Follenzi, A
    Barcia, C
    Sciascia, S
    Castro, MG
    Naldini, L
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    [J]. HUMAN GENE THERAPY, 2005, 16 (06) : 741 - 751
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    Lowenstein, PR
    Abordo-Adesida, E
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    Follenzi, A
    Naldini, L
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    Stone, D
    Xiong, WD
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    [J]. MOLECULAR THERAPY, 2003, 8 (03) : 400 - 411
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    Liu, CY
    Puntel, M
    Sitia, G
    Guidotti, L
    Mitchell, N
    Campbell, I
    Castro, MG
    Lowenstein, PR
    [J]. MOLECULAR THERAPY, 2004, 9 : S390 - S391