A systemically activated immune response eliminates adenoviral-mediated transgene expression from the CNS of rats by cytolitic and non-cytolitic mechanisms

被引:0
|
作者
Barcia, C [1 ]
Zirger, JM [1 ]
Thomas, C [1 ]
Liu, CY [1 ]
Sciascia, SA [1 ]
Castro, MG [1 ]
Lowenstein, PR [1 ]
机构
[1] Cedars Sinai Med Ctr, Gene Therepeut Res Inst, Los Angeles, CA 90048 USA
来源
FASEB JOURNAL | 2005年 / 19卷 / 04期
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中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
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页码:A4 / A4
页数:1
相关论文
共 2 条
  • [1] T-cell responses mediated by IFNγ and perforin eliminate adenoviral-mediated transgene expression from the CNS of mice by cytolytic and non-cytolytic mechanisms
    Zirger, JM
    Barcia, C
    Liu, CY
    Sciascia, S
    Castro, M
    Lowenstein, P
    [J]. FASEB JOURNAL, 2005, 19 (04): : A4 - A4
  • [2] Immune system regulation of transgene expression in the brain 1: Systemically activated immune responses silence adenoviral vector-encoded transgene expression in the brain through both non-cytolytic, and cytotoxic mechanisms
    Barcia, C
    Thomas, C
    Zirger, J
    Xiong, WD
    Boyer, O
    Klatzmann, D
    Castro, MG
    Lowenstein, PR
    [J]. MOLECULAR THERAPY, 2004, 9 : S174 - S175