Kalihioxepanes A-G: Seven Kalihinene Diterpenoids from Marine Sponge Acanthella cavernosa Collected off the South China Sea

被引：12

作者：

Wang, Zhe ^{[1
]}

Han, Xiao ^{[1
]}

Liu, Guoping ^{[1
]}

Zhang, Di ^{[1
]}

Hou, Huiyue ^{[1
]}

Xiao, Li ^{[1
]}

de Voogd, Nicole J. ^{[3
]}

Tang, Xuli ^{[4
]}

Li, Pinglin ^{[1
,2
]}

Li, Guoqiang ^{[1
,2
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Shandong, Peoples R China

[2] Natl Lab Marine Sci & Technol, Lab Marine Drugs & Biol Prod, Qingdao 266235, Shandong, Peoples R China

[3] Natl Museum Nat Hist, NL-2300 RA Leiden, Netherlands

[4] Ocean Univ China, Coll Chem & Chem Engn, Qingdao 266100, Shandong, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2022年 / 40卷 / 15期

基金：

中国国家自然科学基金;

关键词：

Acanthella cavernosa; Kalihinenes; Configuration determination; Cytotoxicity; Natural products; ISONITRILES; ASSAY;

D O I：

10.1002/cjoc.202200120

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Comprehensive Summary Seven new kalihinene diterpenoids, kalihioxepanes A-G (1-7) bearing a rare oxepane ring, were isolated from sponge Acanthella cavernosa collected from the South China Sea. The structures and absolute configurations were elucidated by comprehensive spectroscopic analysis, single crystal X-ray diffraction, and quantum chemical calculation methods. Kalihioxepane A (1) displayed strong cytotoxicity against H69 and K562 tumor cells, while kalihioxepane B (2) showed moderate cytotoxicity against K562 cells.

引用

页码：1785 / 1792

页数：8

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